Immune dysfunction in trauma

L. M. Napolitano, E. Faist, M. W. Wichmann, R. Coimbra

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)


This article documents that all immunomodulation strategies for patients sustaining traumatic injury are still under intense investigation. Although we can speculate that combination strategies may be more beneficial than single-agent immunomodulation approaches, comprehensive clinical studies are required to determine efficacious immune therapy for trauma patients. The only strategy available to clinicians caring for trauma patients is immunonutrition, and this should be strongly considered as a rational approach to improve immune function and reduce septic complications in critically ill or injured patients.

Original languageEnglish
Pages (from-to)1385-1416
Number of pages32
JournalSurgical Clinics of North America
Issue number6
Publication statusPublished - Dec 1999
Externally publishedYes


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