Immune failure, infection and survival in chronic lymphocytic leukemia

Kyle R. Crassini, O. Giles Best, Stephen P. Mulligan

Research output: Contribution to journalLetterpeer-review

7 Citations (Scopus)

Abstract

Chronic lymphocytic leukemia (CLL) commonly leads to immune dysfunction especially hypogammaglobulinemia, increasing risk of infection. Infection remains a major cause of mortality and morbidity in CLL with studies showing this accounts for a third to a half of all deaths. Immunoglobulin G (IgG) is the most prevalent
and frequently monitored immunoglobulin in relation to immune function in CLL. It is widely accepted that there is a relationship between IgG deficiency and infection,
albeit with some dispute in literature.
Original languageEnglish
Pages (from-to)e329
Number of pages1
JournalHaematologica
Volume103
Issue number7
DOIs
Publication statusPublished - Jul 2018
Externally publishedYes

Keywords

  • Chronic Lymphocytic Leukemia (CLL)
  • immune dysfunction
  • hypogammaglobulinemia
  • infection
  • Immunoglobulin G
  • IgG

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