Immune failure, infection and survival in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) commonly leads to immune dysfunction especially hypogammaglobulinemia, increasing risk of infection. Infection remains a major cause of mortality and morbidity in CLL with studies showing this accounts for a third to a half of all deaths. Immunoglobulin G (IgG) is the most prevalent
and frequently monitored immunoglobulin in relation to immune function in CLL. It is widely accepted that there is a relationship between IgG deficiency and infection,
albeit with some dispute in literature.