Immune failure, infection and survival in chronic lymphocytic leukemia

Kyle R. Crassini; O. Giles Best; Stephen P. Mulligan

doi:10.3324/haematol.2018.196543

Immune failure, infection and survival in chronic lymphocytic leukemia

Kyle R. Crassini
, O. Giles Best
, Stephen P. Mulligan

Research output: Contribution to journal › Letter › peer-review

24 Citations (Scopus)

Abstract

Chronic lymphocytic leukemia (CLL) commonly leads to immune dysfunction especially hypogammaglobulinemia, increasing risk of infection. Infection remains a major cause of mortality and morbidity in CLL with studies showing this accounts for a third to a half of all deaths. Immunoglobulin G (IgG) is the most prevalent
and frequently monitored immunoglobulin in relation to immune function in CLL. It is widely accepted that there is a relationship between IgG deficiency and infection,
albeit with some dispute in literature.

Original language	English
Pages (from-to)	e329
Number of pages	1
Journal	Haematologica
Volume	103
Issue number	7
DOIs	https://doi.org/10.3324/haematol.2018.196543
Publication status	Published - Jul 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chronic Lymphocytic Leukemia (CLL)
immune dysfunction
hypogammaglobulinemia
infection
Immunoglobulin G
IgG

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10.3324/haematol.2018.196543Licence: In Copyright

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title = "Immune failure, infection and survival in chronic lymphocytic leukemia",

abstract = "Chronic lymphocytic leukemia (CLL) commonly leads to immune dysfunction especially hypogammaglobulinemia, increasing risk of infection. Infection remains a major cause of mortality and morbidity in CLL with studies showing this accounts for a third to a half of all deaths. Immunoglobulin G (IgG) is the most prevalent and frequently monitored immunoglobulin in relation to immune function in CLL. It is widely accepted that there is a relationship between IgG deficiency and infection, albeit with some dispute in literature.",

keywords = "Chronic Lymphocytic Leukemia (CLL), immune dysfunction, hypogammaglobulinemia, infection, Immunoglobulin G, IgG",

author = "Crassini, \{Kyle R.\} and Best, \{O. Giles\} and Mulligan, \{Stephen P.\}",

year = "2018",

month = jul,

doi = "10.3324/haematol.2018.196543",

language = "English",

volume = "103",

pages = "e329",

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TY - JOUR

T1 - Immune failure, infection and survival in chronic lymphocytic leukemia

AU - Crassini, Kyle R.

AU - Best, O. Giles

AU - Mulligan, Stephen P.

PY - 2018/7

Y1 - 2018/7

N2 - Chronic lymphocytic leukemia (CLL) commonly leads to immune dysfunction especially hypogammaglobulinemia, increasing risk of infection. Infection remains a major cause of mortality and morbidity in CLL with studies showing this accounts for a third to a half of all deaths. Immunoglobulin G (IgG) is the most prevalent and frequently monitored immunoglobulin in relation to immune function in CLL. It is widely accepted that there is a relationship between IgG deficiency and infection, albeit with some dispute in literature.

AB - Chronic lymphocytic leukemia (CLL) commonly leads to immune dysfunction especially hypogammaglobulinemia, increasing risk of infection. Infection remains a major cause of mortality and morbidity in CLL with studies showing this accounts for a third to a half of all deaths. Immunoglobulin G (IgG) is the most prevalent and frequently monitored immunoglobulin in relation to immune function in CLL. It is widely accepted that there is a relationship between IgG deficiency and infection, albeit with some dispute in literature.

KW - Chronic Lymphocytic Leukemia (CLL)

KW - immune dysfunction

KW - hypogammaglobulinemia

KW - infection

KW - Immunoglobulin G

KW - IgG

UR - https://www.scopus.com/pages/publications/85049583567

U2 - 10.3324/haematol.2018.196543

DO - 10.3324/haematol.2018.196543

M3 - Letter

C2 - 29970494

AN - SCOPUS:85049583567

SN - 0390-6078

VL - 103

SP - e329

JO - Haematologica

JF - Haematologica

IS - 7

ER -

Immune failure, infection and survival in chronic lymphocytic leukemia

Abstract

UN SDGs

Keywords

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