Immunoglobulin kappa light chain gene alleles are not associated with primary Sjögren’s syndrome

S. Downie-Doyle, S. Lester, P. Bardy, T. Gordon, M. Rischmueller, K. Pile

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5 Citations (Scopus)


The immunoglobulin kappa (Km) light chain gene is polymorphic and is believed to play a role in the pathology of infectious and autoimmune diseases. Polymorphisms within the constant region of the Km gene encode three alleles designated Km1, Km1, 2 and Km3. Previous studies using serological detection of Km allotypes reported associations between specific Km allotypes, systemic lupus erythematosus and the presence of anti-La antibodies, yet these findings were not confirmed in other studies. In order to more precisely define any associations between Km alleles and anti-Ro/La antibodies we used the polymerase chain reaction and restriction fragment length polymorphisms for Km genotyping in a large cohort of patients with primary Sjögren’s syndrome (SS). No associations were observed between specific Km alleles and primary SS when compared with a control population, nor within serologically defined subsets of SS patients. We conclude that Km alleles are not associated with primary SS or the Ro/La autoantibody response.

Original languageEnglish
Pages (from-to)S63-S65
JournalGenes and Immunity
Publication statusPublished - Oct 2002
Externally publishedYes


  • Immunoglobulins
  • Km allotypes
  • Polymorphism
  • Sjogren’s syndrome


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