Immunohistochemical detection of cytokines and cell adhesion molecules in the synovial membrane

Angela Parker, Malcolm D. Smith

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    This paper describes the immunohistochemical techniques which can be used to detect cytokines and cell adhesion molecules in synovial membrane tissue, including a list of reagents and possible problems in each technique. It also describes three methods of quantitation of the resultant immunohistochemical detection, including the recent innovation computer- assisted digital video image analysis, and lists the advantages and disadvantages of each quantitation technique. This information will be a useful summary for any scientist interested in applying such techniques to the detection of cytokines and cell adhesion molecules in human tissue sections.

    Original languageEnglish
    Pages (from-to)311-319
    Number of pages9
    JournalMethods and Findings in Experimental and Clinical Pharmacology
    Volume21
    Issue number5
    DOIs
    Publication statusPublished - 1999

    Keywords

    • Cell adhesion molecules
    • Cytokines
    • Immunohistochemistry
    • Quantitation

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