Immunohistochemical evidence for the distribution of nerve growth factor in the embryonic mouse

P. J. Finn; I. A. Ferguson; P. A. Wilson; J. Vahaviolos; R. A. Rush

doi:10.1007/BF01637656

Immunohistochemical evidence for the distribution of nerve growth factor in the embryonic mouse

P. J. Finn, I. A. Ferguson, P. A. Wilson, J. Vahaviolos, R. A. Rush

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Abstract

The distribution of nerve growth factor-like immunoreactivity has been examined in the embryonic mouse with special reference to the CNS. The intensity of the immunoreactive stain was found to be greatest on embryonic days 15 and 16. The antigen is widespread and present in high concentrations in both the PNS and CNS. Most intense staining was detected in cranial nerve tracts, hippocampus, developing white matter of the spinal cord and tegmentum. Lower intensities were found within diencephalic regions, spinal cord grey matter, medullary fibre tracts and cerebellum. These results support the increasing evidence suggesting that the trophic molecule nerve growth factor has an important role to play in the development of central as well as peripheral neurons.

Original language	English
Pages (from-to)	639-647
Number of pages	9
Journal	Journal of Neurocytology
Volume	16
Issue number	5
DOIs	https://doi.org/10.1007/BF01637656
Publication status	Published - Oct 1987

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Finn, P. J., Ferguson, I. A., Wilson, P. A., Vahaviolos, J., & Rush, R. A. (1987). Immunohistochemical evidence for the distribution of nerve growth factor in the embryonic mouse. Journal of Neurocytology, 16(5), 639-647. https://doi.org/10.1007/BF01637656

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AU - Rush, R. A.

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