Immunologie bei Schwerverletzten

Translated title of the contribution: Immunological finding in patients with major multiple trauma

E. Faist, M. W. Wichmann

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Immunologial complications frequently occur during the clinical course in patients with multiple injuries. The increased release of pro-inflammatory mediators during the immunological response to trauma may lead to the systemic inflammatory response syndrome (SIRS) and furthermore, to multisystem organ failure (MOF), which is associated with a mortality of up to 80%. The development of multiple organ failure following major trauma is associated with remote organ failure, the dysfunction of organs which were not initially affected by the traum. This manuscript reviews recent data in experimental trauma research and offers a more detailed evaluation of the immunological findings in trauma patients. In particular, the role of pro- and anti-inflammatory cytokines in the development or SIRS, MOF and ROF is discussed. Despite the enormous progress in clinical immunology and the available data on trauma-induced immune dysfunction, a large number of questions still remain to be answered before the immunological alterations following severe trauma can be beneficially influenced by immunomodulatory therapeutic efforts.

Translated title of the contributionImmunological finding in patients with major multiple trauma
Original languageGerman
Pages (from-to)1066-1070
Number of pages5
Publication statusPublished - Nov 1997
Externally publishedYes


  • Cytokines
  • Immunology
  • MOF
  • SIRS
  • Traum


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