Immunospecific targeting of CD45 expressing lymphoid cells: Towards improved detection agents of the sentinel lymph node

Tianqing Liu, Aidan Cousins, Chia Chi Chien, Ivan Kempson, Sarah Thompson, Yeukuang Hwu, Benjamin Thierry

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study was designed to demonstrate the potential of small nanoparticulate lymphotropic contrast agents designed to bind with high affinity to lymphoid cells overexpressing the CD45 antigen. To this end, small gold nanoparticles used as model were conjugated to anti-CD45 antibodies and injected in mice in the dorsal toe of the fore/hind paw. Chemical analysis demonstrated rapid uptake and transport of the nanoparticles in the lymphatic as well as significant retention of the nanoparticles with high binding affinity to lymphoid cells in the popliteal and axillary lymph nodes in comparison to non-targeted nanoparticles.

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalCancer Letters
Volume328
Issue number2
DOIs
Publication statusPublished - 28 Jan 2013
Externally publishedYes

Keywords

  • Anti-CD45 immunotargeting
  • Gold nanoparticles
  • Lymphatic transport
  • Sentinel lymph node

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