Immunospecific targeting of CD45 expressing lymphoid cells: Towards improved detection agents of the sentinel lymph node

Tianqing Liu; Aidan Cousins; Chia Chi Chien; Ivan Kempson; Sarah Thompson; Yeukuang Hwu; Benjamin Thierry

doi:10.1016/j.canlet.2012.09.024

Immunospecific targeting of CD45 expressing lymphoid cells: Towards improved detection agents of the sentinel lymph node

Tianqing Liu, Aidan Cousins, Chia Chi Chien, Ivan Kempson, Sarah Thompson, Yeukuang Hwu, Benjamin Thierry

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

This study was designed to demonstrate the potential of small nanoparticulate lymphotropic contrast agents designed to bind with high affinity to lymphoid cells overexpressing the CD45 antigen. To this end, small gold nanoparticles used as model were conjugated to anti-CD45 antibodies and injected in mice in the dorsal toe of the fore/hind paw. Chemical analysis demonstrated rapid uptake and transport of the nanoparticles in the lymphatic as well as significant retention of the nanoparticles with high binding affinity to lymphoid cells in the popliteal and axillary lymph nodes in comparison to non-targeted nanoparticles.

Original language	English
Pages (from-to)	271-277
Number of pages	7
Journal	Cancer Letters
Volume	328
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2012.09.024
Publication status	Published - 28 Jan 2013
Externally published	Yes

Keywords

Anti-CD45 immunotargeting
Gold nanoparticles
Lymphatic transport
Sentinel lymph node

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2012.09.024Licence: In Copyright

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title = "Immunospecific targeting of CD45 expressing lymphoid cells: Towards improved detection agents of the sentinel lymph node",

abstract = "This study was designed to demonstrate the potential of small nanoparticulate lymphotropic contrast agents designed to bind with high affinity to lymphoid cells overexpressing the CD45 antigen. To this end, small gold nanoparticles used as model were conjugated to anti-CD45 antibodies and injected in mice in the dorsal toe of the fore/hind paw. Chemical analysis demonstrated rapid uptake and transport of the nanoparticles in the lymphatic as well as significant retention of the nanoparticles with high binding affinity to lymphoid cells in the popliteal and axillary lymph nodes in comparison to non-targeted nanoparticles.",

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AU - Liu, Tianqing

AU - Cousins, Aidan

AU - Chien, Chia Chi

AU - Kempson, Ivan

AU - Thompson, Sarah

AU - Hwu, Yeukuang

AU - Thierry, Benjamin

PY - 2013/1/28

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AB - This study was designed to demonstrate the potential of small nanoparticulate lymphotropic contrast agents designed to bind with high affinity to lymphoid cells overexpressing the CD45 antigen. To this end, small gold nanoparticles used as model were conjugated to anti-CD45 antibodies and injected in mice in the dorsal toe of the fore/hind paw. Chemical analysis demonstrated rapid uptake and transport of the nanoparticles in the lymphatic as well as significant retention of the nanoparticles with high binding affinity to lymphoid cells in the popliteal and axillary lymph nodes in comparison to non-targeted nanoparticles.

KW - Anti-CD45 immunotargeting

KW - Gold nanoparticles

KW - Lymphatic transport

KW - Sentinel lymph node

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JF - Cancer Letters

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ER -

Immunospecific targeting of CD45 expressing lymphoid cells: Towards improved detection agents of the sentinel lymph node

Abstract

Keywords

UN SDGs

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