Impact of cardiac dysfunction on morbidity and mortality in liver transplant candidates

Fadak Mohammadi, Jeyamani Ramachandran, Richard Woodman, Kate Muller, Libby John, John Chen, Alan Wigg

Research output: Contribution to journalArticlepeer-review

Abstract

The prognostic role of cardiac dysfunction in cirrhotic patients is increasingly recognised. We studied its impact on morbidity and mortality before and after liver transplantation (LT) including development of post-transplant cardiovascular disease (CVD). In this retrospective study, cirrhotic patients who underwent LT assessment from January 2010 to December 2020 were reviewed. Demographics, cardiac investigations and clinical course were analysed to identify prevalence of cardiac dysfunction and its role in LT outcomes. Survival analysis was performed using Cox proportional hazard regression modelling, with LT as a time-varying covariate and as an interaction variable with cardiac dysfunction. 308 patients (70% male) were studied. The median (interquartile range) age at LT assessment was 56 (12) years. Cardiac dysfunction was found in 178 (58%) patients (diastolic, 169; systolic, 26; both, 17) and was significantly associated with hepatorenal syndrome/acute kidney injury and peri- and post-transplant morbidity (adjusted odds ratio [aOR] 1.94, 95%CI 1.06–3.52, p < 0.001; aOR 2.01, 95%CI 1.06–3.82, p = 0.033; aOR 1.9, 95%CI 1.01–3.65, p = 0.023, respectively). Cardiac dysfunction was not associated with mortality before (adjusted hazard ratio [aHR] 1.01, 95% CI 0.99-1.01) or after LT (aHR 0.74, 95% CI 0.4-1.05. Post-transplant CVD (61% cardiac failure) occurred in 36 patients and consisted with no significant association with cardiac dysfunction (p = 0.11). Cardiac dysfunction was common in LT candidates and was significantly associated with morbidity before and after LT. Studies on the role of advanced echocardiographic parameters to improve diagnosis of cardiac dysfunction and optimise LT outcomes are needed.
Original languageEnglish
Article numbere14682
Number of pages8
JournalCLINICAL TRANSPLANTATION
Early online date19 Apr 2022
DOIs
Publication statusE-pub ahead of print - 19 Apr 2022

Keywords

  • cardiac dysfunction
  • cirrhosis
  • cirrhotic cardiomyopathy
  • liver transplantation
  • morbidity and mortality
  • cardiovascular disease

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