Impact of Surgical and Transcatheter Aortic Valve Replacement on Frailty Score

Dylan R. Jones, Derek P. Chew, Matthew J. Horsfall, Ajay R. Sinhal, Majo X. Joseph, Robert A. Baker, Jayme S. Bennetts, Joseph B. Selvanayagam, Josephine H. Harris, Carmine G. De Pasquale, Sam J. Lehman

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Objective: Frailty is common in the aortic stenosis (AS) population and impacts outcomes after both transcatheter and surgical aortic valve replacement (TAVR and sAVR, respectively). Frailty can significantly impact the decision regarding the suitability of a patient for aortic valve intervention, with frail patients often excluded. Since many frailty tools use indicators which may be influenced by AS itself, some of which are subjectively symptom driven, we sought to determine the impact of intervention on frailty scores. Methods: A prospective, observational cohort study included patients being assessed for aortic valve (AV) intervention with either TAVR or sAVR due to severe aortic stenosis. Patients were assessed for symptoms at baseline, and 1- and 6-months post intervention subjectively, using the New York Heart Association (NYHA) class and the Kansas City Cardiomyopathy Questionnaire (KCCQ), and objectively, using a 6-minute walk test (6MWT). These were compared with frailty at baseline and final review using the Fried Frailty Scale (FFS). Results and Conclusions: Sixty-six (66) patients completed pre- and post-intervention reviews. The mean FFS score was significantly lower, indicating less frailty, at 6 months relative to pre procedure (1.18 vs 1.73, p=0.002). This correlated with the change in symptoms (p<0.001). Between intervention groups, the final mean FFS of both groups decreased significantly, with TAVR to 1.33 (p=0.030) and sAVR to 0.8 (p=0.015). There was no difference in the degree of improvement between interventions (p=0.517). Aortic valve intervention improves frailty scores in both TAVR and sAVR treated patients.

Original languageEnglish
Pages (from-to)566-574
Number of pages9
JournalHeart Lung and Circulation
Issue number4
Early online date14 Oct 2021
Publication statusPublished - Apr 2022


  • Aortic stenosis
  • Aortic valve replacement
  • Frailty
  • Symptoms
  • TAVR


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