In vitro approaches can predict human drug metabolism

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Classical approaches to characterizing the pharmacokinetics, metabolism and interactions of new drugs have involved animal studies to define potential metabolic pathways, phase I studies in humans that often use the radio-labelled compound to define actual pathways, and drug interaction studies in volunteer subjects and patients.
Original languageEnglish
Pages (from-to)292-294
Number of pages3
JournalTrends in Pharmacological Sciences
Issue number8
Publication statusPublished - Aug 1993
Externally publishedYes


  • in vitro
  • metabolism
  • drugs


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