In vitro approaches can predict human drug metabolism

D. J. Birkett; P. I. Mackenzie; M. E. Veronese; J. O. Miners

doi:10.1016/0165-6147(93)90043-J

In vitro approaches can predict human drug metabolism

D. J. Birkett, P. I. Mackenzie, M. E. Veronese, J. O. Miners

Research output: Contribution to journal › Article › peer-review

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Abstract

Classical approaches to characterizing the pharmacokinetics, metabolism and interactions of new drugs have involved animal studies to define potential metabolic pathways, phase I studies in humans that often use the radio-labelled compound to define actual pathways, and drug interaction studies in volunteer subjects and patients.

Original language	English
Pages (from-to)	292-294
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	14
Issue number	8
DOIs	https://doi.org/10.1016/0165-6147(93)90043-J
Publication status	Published - Aug 1993
Externally published	Yes

Keywords

in vitro
metabolism
drugs

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10.1016/0165-6147(93)90043-J

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title = "In vitro approaches can predict human drug metabolism",

abstract = "Classical approaches to characterizing the pharmacokinetics, metabolism and interactions of new drugs have involved animal studies to define potential metabolic pathways, phase I studies in humans that often use the radio-labelled compound to define actual pathways, and drug interaction studies in volunteer subjects and patients. ",

keywords = "in vitro, metabolism, drugs",

author = "Birkett, {D. J.} and Mackenzie, {P. I.} and Veronese, {M. E.} and Miners, {J. O.}",

year = "1993",

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AU - Mackenzie, P. I.

AU - Veronese, M. E.

AU - Miners, J. O.

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KW - drugs

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DO - 10.1016/0165-6147(93)90043-J

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JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 8

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In vitro approaches can predict human drug metabolism

Abstract

Keywords

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