In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ 1-42 ) toxicity and aggregation

Mousa Alghazwi, Scott Smid, Ian Musgrave, Wei Zhang

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Amyloid beta (Aβ) can aggregate and form plaques, which are considered as one of the major hallmarks of Alzheimer's disease. This study aims to directly compare the neuroprotective activities in vitro of two marine-derived carotenoids astaxanthin and fucoxanthin that have shown a spectrum of biological activities, including neuroprotection. The in vitro neuroprotective activities were investigated against Aβ 1-42 -mediated toxicity in pheochromocytoma (PC-12) neuronal cells using the MTT cell viability assay, anti-apoptotic, antioxidant and neurite outgrowth activities; as well as inhibition against Aβ 1-42 fibrillization in the Thioflavin T (ThT) assay of fibril kinetics and via transmission electron microscopic (TEM) evaluation of fibril morphology. The results demonstrated that both astaxanthin and fucoxanthin exhibited multi-neuroprotective effects favouring fucoxanthin over astaxanthin supporting neuroprotective roles of marine-derived carotenoids as potential novel dementia prevention or therapeutic strategies.

    Original languageEnglish
    Pages (from-to)215-224
    Number of pages10
    JournalNeurochemistry International
    Volume124
    DOIs
    Publication statusPublished - Mar 2019

    Keywords

    • Alzheimer's disease
    • Amyloid beta
    • Astaxanthin
    • Fucoxanthin
    • Neuroprotection

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