In Vivo Activity of Benzoyl Ester Clerodane Diterpenoid Derivatives from Dodonaea polyandra

Bradley Simpson, David Claudie, Jacobus Gerber, Simon Pyke, Jiping Wang, Ross McKinnon, Susan Semple

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    Four new benzoyl ester clerodane diterpenoids, 15,16-epoxy-8α- (benzoyloxy)methylcleroda-3,13(16),14-trien-18-oic acid (1), 15,16-epoxy-8α-(benzoyloxy)methyl-2α-hydroxycleroda-3,13(16), 14-trien-18-oic acid (2), 15,16-epoxy-8α-(benzoyloxy)methyl-2-oxocleroda- 3,13(16),14-trien-18-oic acid (3), and 15,16-epoxy-2α-benzoyloxycleroda-3, 13(16),14-trien-18-oic acid (4), have been isolated from the leaves and stems of Dodonaea polyandra. The anti-inflammatory activities of compounds 1, 2, and 4 were evaluated by means of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Compounds 2 and 4 exhibited maximum inhibition of inflammation (70-76%) at doses of 0.22 and 0.9 μmol/ear, respectively. Modest activity (45% inhibition) was maintained at nanomole/ear doses.

    Original languageEnglish
    Pages (from-to)650-657
    Number of pages8
    JournalJournal of Natural Products
    Volume74
    Issue number4
    DOIs
    Publication statusPublished - 2011

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