TY - JOUR
T1 - In Vivo Activity of Benzoyl Ester Clerodane Diterpenoid Derivatives from Dodonaea polyandra
AU - Simpson, Bradley
AU - Claudie, David
AU - Gerber, Jacobus
AU - Pyke, Simon
AU - Wang, Jiping
AU - McKinnon, Ross
AU - Semple, Susan
PY - 2011/4/25
Y1 - 2011/4/25
N2 - Four new benzoyl ester clerodane diterpenoids, 15,16-epoxy-8α- (benzoyloxy)methylcleroda-3,13(16),14-trien-18-oic acid (1), 15,16-epoxy-8α-(benzoyloxy)methyl-2α-hydroxycleroda-3,13(16), 14-trien-18-oic acid (2), 15,16-epoxy-8α-(benzoyloxy)methyl-2-oxocleroda- 3,13(16),14-trien-18-oic acid (3), and 15,16-epoxy-2α-benzoyloxycleroda-3, 13(16),14-trien-18-oic acid (4), have been isolated from the leaves and stems of Dodonaea polyandra. The anti-inflammatory activities of compounds 1, 2, and 4 were evaluated by means of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Compounds 2 and 4 exhibited maximum inhibition of inflammation (70-76%) at doses of 0.22 and 0.9 μmol/ear, respectively. Modest activity (45% inhibition) was maintained at nanomole/ear doses.
AB - Four new benzoyl ester clerodane diterpenoids, 15,16-epoxy-8α- (benzoyloxy)methylcleroda-3,13(16),14-trien-18-oic acid (1), 15,16-epoxy-8α-(benzoyloxy)methyl-2α-hydroxycleroda-3,13(16), 14-trien-18-oic acid (2), 15,16-epoxy-8α-(benzoyloxy)methyl-2-oxocleroda- 3,13(16),14-trien-18-oic acid (3), and 15,16-epoxy-2α-benzoyloxycleroda-3, 13(16),14-trien-18-oic acid (4), have been isolated from the leaves and stems of Dodonaea polyandra. The anti-inflammatory activities of compounds 1, 2, and 4 were evaluated by means of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Compounds 2 and 4 exhibited maximum inhibition of inflammation (70-76%) at doses of 0.22 and 0.9 μmol/ear, respectively. Modest activity (45% inhibition) was maintained at nanomole/ear doses.
UR - http://www.scopus.com/inward/record.url?scp=79955399035&partnerID=8YFLogxK
U2 - 10.1021/np100701s
DO - 10.1021/np100701s
M3 - Article
VL - 74
SP - 650
EP - 657
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 4
ER -