In vivo mutagenic effect of VERY low dose radiation

Pamela J. Sykes, Tanya K. Day, Sarah J. Swinburne, Joanne M. Lane, Madhava Bhat, Alexander A. Morley, Antony M. Hooker

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    Abstract

    Almost all of our knowledge about the mutational effect of radiation has come from high dose studies, which are generally not relevant to public exposure. The pKZ1 mouse recombination mutagenesis assay enables study of the mutational effect of very low doses of low LET radiation (μGy to cGy range) in a whole animal model. The mutational end-point studied is chromosomal inversion, which is a common mutation in cancer. We have observed 1) a non-linear dose response of induced inversions in pKZ1 mice exposed to a wide dose range of low LET radiation, 2) the ability of low priming doses to cause an adaptive response to subsequent higher test doses and 3) the effect of genetic susceptibility where animals that are heterozygous for the Ataxia Telangiectasia gene exhibit (Atm) different responses to low dose radiation compared to their normal littermates.

    Original languageEnglish
    Title of host publicationThe 14th Pacific Basin Nuclear Conference
    Pages19
    Number of pages1
    ISBN (Electronic)9780894486791
    Publication statusPublished - 2004
    Event14th Pacific Basin Nuclear Conference - Honolulu, HI, United States
    Duration: 21 Mar 200425 Mar 2004

    Conference

    Conference14th Pacific Basin Nuclear Conference
    CountryUnited States
    CityHonolulu, HI
    Period21/03/0425/03/04

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