In vivo mutagenic effect of VERY low dose radiation

Pamela J. Sykes; Tanya K. Day; Sarah J. Swinburne; Joanne M. Lane; Madhava Bhat; Alexander A. Morley; Antony M. Hooker

In vivo mutagenic effect of VERY low dose radiation

Pamela J. Sykes, Tanya K. Day, Sarah J. Swinburne, Joanne M. Lane, Madhava Bhat, Alexander A. Morley, Antony M. Hooker

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Almost all of our knowledge about the mutational effect of radiation has come from high dose studies, which are generally not relevant to public exposure. The pKZ1 mouse recombination mutagenesis assay enables study of the mutational effect of very low doses of low LET radiation (μGy to cGy range) in a whole animal model. The mutational end-point studied is chromosomal inversion, which is a common mutation in cancer. We have observed 1) a non-linear dose response of induced inversions in pKZ1 mice exposed to a wide dose range of low LET radiation, 2) the ability of low priming doses to cause an adaptive response to subsequent higher test doses and 3) the effect of genetic susceptibility where animals that are heterozygous for the Ataxia Telangiectasia gene exhibit (Atm) different responses to low dose radiation compared to their normal littermates.

Original language	English
Title of host publication	The 14th Pacific Basin Nuclear Conference
Pages	19
Number of pages	1
ISBN (Electronic)	9780894486791
Publication status	Published - 2004
Event	14th Pacific Basin Nuclear Conference - Honolulu, HI, United States Duration: 21 Mar 2004 → 25 Mar 2004

Conference

Conference	14th Pacific Basin Nuclear Conference
Country/Territory	United States
City	Honolulu, HI
Period	21/03/04 → 25/03/04

Cite this

@inproceedings{76f1effdca0644b9a6e66a86cf6f02b0,

title = "In vivo mutagenic effect of VERY low dose radiation",

abstract = "Almost all of our knowledge about the mutational effect of radiation has come from high dose studies, which are generally not relevant to public exposure. The pKZ1 mouse recombination mutagenesis assay enables study of the mutational effect of very low doses of low LET radiation (μGy to cGy range) in a whole animal model. The mutational end-point studied is chromosomal inversion, which is a common mutation in cancer. We have observed 1) a non-linear dose response of induced inversions in pKZ1 mice exposed to a wide dose range of low LET radiation, 2) the ability of low priming doses to cause an adaptive response to subsequent higher test doses and 3) the effect of genetic susceptibility where animals that are heterozygous for the Ataxia Telangiectasia gene exhibit (Atm) different responses to low dose radiation compared to their normal littermates.",

author = "Sykes, {Pamela J.} and Day, {Tanya K.} and Swinburne, {Sarah J.} and Lane, {Joanne M.} and Madhava Bhat and Morley, {Alexander A.} and Hooker, {Antony M.}",

year = "2004",

language = "English",

pages = "19",

booktitle = "The 14th Pacific Basin Nuclear Conference",

note = "14th Pacific Basin Nuclear Conference ; Conference date: 21-03-2004 Through 25-03-2004",

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TY - GEN

T1 - In vivo mutagenic effect of VERY low dose radiation

AU - Sykes, Pamela J.

AU - Day, Tanya K.

AU - Swinburne, Sarah J.

AU - Lane, Joanne M.

AU - Bhat, Madhava

AU - Morley, Alexander A.

AU - Hooker, Antony M.

PY - 2004

Y1 - 2004

N2 - Almost all of our knowledge about the mutational effect of radiation has come from high dose studies, which are generally not relevant to public exposure. The pKZ1 mouse recombination mutagenesis assay enables study of the mutational effect of very low doses of low LET radiation (μGy to cGy range) in a whole animal model. The mutational end-point studied is chromosomal inversion, which is a common mutation in cancer. We have observed 1) a non-linear dose response of induced inversions in pKZ1 mice exposed to a wide dose range of low LET radiation, 2) the ability of low priming doses to cause an adaptive response to subsequent higher test doses and 3) the effect of genetic susceptibility where animals that are heterozygous for the Ataxia Telangiectasia gene exhibit (Atm) different responses to low dose radiation compared to their normal littermates.

AB - Almost all of our knowledge about the mutational effect of radiation has come from high dose studies, which are generally not relevant to public exposure. The pKZ1 mouse recombination mutagenesis assay enables study of the mutational effect of very low doses of low LET radiation (μGy to cGy range) in a whole animal model. The mutational end-point studied is chromosomal inversion, which is a common mutation in cancer. We have observed 1) a non-linear dose response of induced inversions in pKZ1 mice exposed to a wide dose range of low LET radiation, 2) the ability of low priming doses to cause an adaptive response to subsequent higher test doses and 3) the effect of genetic susceptibility where animals that are heterozygous for the Ataxia Telangiectasia gene exhibit (Atm) different responses to low dose radiation compared to their normal littermates.

UR - http://www.scopus.com/inward/record.url?scp=13244268298&partnerID=8YFLogxK

UR - https://www.ans.org/store/item-700305/

M3 - Conference contribution

AN - SCOPUS:13244268298

SP - 19

BT - The 14th Pacific Basin Nuclear Conference

T2 - 14th Pacific Basin Nuclear Conference

Y2 - 21 March 2004 through 25 March 2004

ER -

In vivo mutagenic effect of VERY low dose radiation

Abstract

Conference

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