Inappropriate antidiuretic hormone secretion, abdominal pain and disseminated varicella-zoster virus infection: An unusual triad in a patient 6 months post mini-allogeneic peripheral stem cell transplant for chronic myeloid leukemia

F. Szabó, N. Horvath, S. Seimon, T. Hughes

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19 Citations (Scopus)

Abstract

Severe abdominal pain followed by inappropriate antidiuretic hormone secretion (SIADH) preceding by several days the skin manifestation of varicella-zoster virus (VZV) infection in an immunocompromised patient is described. This is a rare presentation of a severe infection described previously only once in a chronic myeloid leukemia (CML) patient 5 months post allo-BMT during immunosuppressive treatment with cyclosporin A. This is the first case described in the setting of non-myeloablative preparation with fludarabine and melphalan and followed by donor leukocyte infusion (DLI) 2 and 4 months post allo-BMT. The influence of these factors on development of VZV virus infection is discussed. We also highlight the high incidence and high mortality in VZV infection in immunocompromised patients as well as the frequent atypical presentation.

Original languageEnglish
Pages (from-to)231-233
Number of pages3
JournalBONE MARROW TRANSPLANTATION
Volume26
Issue number2
DOIs
Publication statusPublished - 17 Jul 2000
Externally publishedYes

Keywords

  • Abdominal pain
  • Bone marrow transplantation
  • Inappropriate antidiuretic hormone secretion
  • Varicella-zoster virus infection

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