Incidence and prevalence of NMOSD in Australia and New Zealand

Wajih Bukhari; Kerri Prain; Patrick Waters; Mark Woodhall; Cullen O'Gorman; Laura Clarke; Roger Silvestrini; Christine Bundell; David Abernethy; Sandeep Bhuta; Stefan Blum; Mike Boggild; Karyn Boundy; Bruce J Brew; Matthew Brown; Wallace Brownlee; Helmut Butzkueven; William Carroll; Celia Chen; Alan Coulthard; Russell Dale; Chandi Das; Keith Dear; Marzena Fabis-Pedrini; David Fulcher; David Gillis; Simon Hawke; Robert Heard; Andrew P D Henderson; Saman Heshmat; Suzanne Hodgkinson; Sofia Jimenez-Sanchez; Trevor Killpatrick; John King; Chris Kneebone; Andrew Kornberg; Jeannette Lechner-Scott; Ming-Wei Lin; Christopher Lynch; Richard Macdonell; Deborah F Mason; Pamela McCombe; Michael Pender; Jennifer Pereira; John Pollard; Stephen Reddel; Cameron Shaw; Judith Spies; James Stankovich; Ian Sutton; Steve Vucic; Michael Walsh; Richard C Wong; Eppie Yiu; Michael Barnett; Allan Kermode; Mark Marriott; John Parratt; Mark Slee; Bruce Taylor; Ernest Willoughby; Robert Wilson; Angela Vincent; Simon Broadly

doi:10.1136/jnnp-2016-314839

Incidence and prevalence of NMOSD in Australia and New Zealand

Wajih Bukhari, Kerri Prain, Patrick Waters, Mark Woodhall, Cullen O'Gorman, Laura Clarke, Roger Silvestrini, Christine Bundell, David Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J Brew, Matthew Brown, Wallace Brownlee, Helmut Butzkueven, William Carroll, Celia Chen, Alan CoulthardRussell Dale, Chandi Das, Keith Dear, Marzena Fabis-Pedrini, David Fulcher, David Gillis, Simon Hawke, Robert Heard, Andrew P D Henderson, Saman Heshmat, Suzanne Hodgkinson, Sofia Jimenez-Sanchez, Trevor Killpatrick, John King, Chris Kneebone, Andrew Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christopher Lynch, Richard Macdonell, Deborah F Mason, Pamela McCombe, Michael Pender, Jennifer Pereira, John Pollard, Stephen Reddel, Cameron Shaw, Judith Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C Wong, Eppie Yiu, Michael Barnett, Allan Kermode, Mark Marriott, John Parratt, Mark Slee, Bruce Taylor, Ernest Willoughby, Robert Wilson, Angela Vincent, Simon Broadly

Research output: Contribution to journal › Article › peer-review

104 Citations (Scopus)

Abstract

Objectives: We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry. Background: NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established. Methods: Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD. Testing for aquaporin 4 antibodies was undertaken in all suspected cases. From this group, cases were identified who fulfilled the 2015 Wingerchuk diagnostic criteria for NMOSD. A capture-recapture methodology was used to estimate incidence and prevalence, based on additional laboratory identified cases. Results: NMOSD was confirmed in 81/170 (48%) cases referred. Capture-recapture analysis gave an adjusted incidence estimate of 0.37 (95% CI 0.35 to 0.39) per million per year and a prevalence estimate for NMOSD of 0.70 (95% CI 0.61 to 0.78) per 100 000. NMOSD was three times more common in the Asian population (1.57 (95% CI 1.15 to 1.98) per 100 000) compared with the remainder of the population (0.57 (95% CI 0.50 to 0.65) per 100 000). The latitudinal gradient evident in multiple sclerosis was not seen in NMOSD. Conclusions: NMOSD incidence and prevalence in Australia and New Zealand are comparable with figures from other populations of largely European ancestry. We found NMOSD to be more common in the population with Asian ancestry.

Original language	English
Pages (from-to)	632-638
Number of pages	7
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	88
Issue number	8
DOIs	https://doi.org/10.1136/jnnp-2016-314839
Publication status	Published - 1 Aug 2017

Keywords

Ancestry
Epidemiology
Incidence
Neuroimmunology
Prevalence

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Bukhari, W., Prain, K., Waters, P., Woodhall, M., O'Gorman, C., Clarke, L., Silvestrini, R., Bundell, C., Abernethy, D., Bhuta, S., Blum, S., Boggild, M., Boundy, K., Brew, B. J., Brown, M., Brownlee, W., Butzkueven, H., Carroll, W., Chen, C., ... Broadly, S. (2017). Incidence and prevalence of NMOSD in Australia and New Zealand. Journal of Neurology, Neurosurgery and Psychiatry, 88(8), 632-638. https://doi.org/10.1136/jnnp-2016-314839

@article{051d50abccdc4c9daf9d27949626fbb9,

title = "Incidence and prevalence of NMOSD in Australia and New Zealand",

abstract = "Objectives: We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry. Background: NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established. Methods: Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD. Testing for aquaporin 4 antibodies was undertaken in all suspected cases. From this group, cases were identified who fulfilled the 2015 Wingerchuk diagnostic criteria for NMOSD. A capture-recapture methodology was used to estimate incidence and prevalence, based on additional laboratory identified cases. Results: NMOSD was confirmed in 81/170 (48%) cases referred. Capture-recapture analysis gave an adjusted incidence estimate of 0.37 (95% CI 0.35 to 0.39) per million per year and a prevalence estimate for NMOSD of 0.70 (95% CI 0.61 to 0.78) per 100 000. NMOSD was three times more common in the Asian population (1.57 (95% CI 1.15 to 1.98) per 100 000) compared with the remainder of the population (0.57 (95% CI 0.50 to 0.65) per 100 000). The latitudinal gradient evident in multiple sclerosis was not seen in NMOSD. Conclusions: NMOSD incidence and prevalence in Australia and New Zealand are comparable with figures from other populations of largely European ancestry. We found NMOSD to be more common in the population with Asian ancestry.",

keywords = "Ancestry, Epidemiology, Incidence, Neuroimmunology, Prevalence",

author = "Wajih Bukhari and Kerri Prain and Patrick Waters and Mark Woodhall and Cullen O'Gorman and Laura Clarke and Roger Silvestrini and Christine Bundell and David Abernethy and Sandeep Bhuta and Stefan Blum and Mike Boggild and Karyn Boundy and Brew, {Bruce J} and Matthew Brown and Wallace Brownlee and Helmut Butzkueven and William Carroll and Celia Chen and Alan Coulthard and Russell Dale and Chandi Das and Keith Dear and Marzena Fabis-Pedrini and David Fulcher and David Gillis and Simon Hawke and Robert Heard and Henderson, {Andrew P D} and Saman Heshmat and Suzanne Hodgkinson and Sofia Jimenez-Sanchez and Trevor Killpatrick and John King and Chris Kneebone and Andrew Kornberg and Jeannette Lechner-Scott and Ming-Wei Lin and Christopher Lynch and Richard Macdonell and Mason, {Deborah F} and Pamela McCombe and Michael Pender and Jennifer Pereira and John Pollard and Stephen Reddel and Cameron Shaw and Judith Spies and James Stankovich and Ian Sutton and Steve Vucic and Michael Walsh and Wong, {Richard C} and Eppie Yiu and Michael Barnett and Allan Kermode and Mark Marriott and John Parratt and Mark Slee and Bruce Taylor and Ernest Willoughby and Robert Wilson and Angela Vincent and Simon Broadly",

year = "2017",

month = aug,

day = "1",

doi = "10.1136/jnnp-2016-314839",

language = "English",

volume = "88",

pages = "632--638",

journal = "Journal of Neurology, Neurosurgery and Psychiatry",

issn = "0022-3050",

publisher = "BMJ Publishing Group Ltd",

number = "8",

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Bukhari, W, Prain, K, Waters, P, Woodhall, M, O'Gorman, C, Clarke, L, Silvestrini, R, Bundell, C, Abernethy, D, Bhuta, S, Blum, S, Boggild, M, Boundy, K, Brew, BJ, Brown, M, Brownlee, W, Butzkueven, H, Carroll, W, Chen, C, Coulthard, A, Dale, R, Das, C, Dear, K, Fabis-Pedrini, M, Fulcher, D, Gillis, D, Hawke, S, Heard, R, Henderson, APD, Heshmat, S, Hodgkinson, S, Jimenez-Sanchez, S, Killpatrick, T, King, J, Kneebone, C, Kornberg, A, Lechner-Scott, J, Lin, M-W, Lynch, C, Macdonell, R, Mason, DF, McCombe, P, Pender, M, Pereira, J, Pollard, J, Reddel, S, Shaw, C, Spies, J, Stankovich, J, Sutton, I, Vucic, S, Walsh, M, Wong, RC, Yiu, E, Barnett, M, Kermode, A, Marriott, M, Parratt, J, Slee, M, Taylor, B, Willoughby, E, Wilson, R, Vincent, A & Broadly, S 2017, 'Incidence and prevalence of NMOSD in Australia and New Zealand', Journal of Neurology, Neurosurgery and Psychiatry, vol. 88, no. 8, pp. 632-638. https://doi.org/10.1136/jnnp-2016-314839

TY - JOUR

T1 - Incidence and prevalence of NMOSD in Australia and New Zealand

AU - Bukhari, Wajih

AU - Prain, Kerri

AU - Waters, Patrick

AU - Woodhall, Mark

AU - O'Gorman, Cullen

AU - Clarke, Laura

AU - Silvestrini, Roger

AU - Bundell, Christine

AU - Abernethy, David

AU - Bhuta, Sandeep

AU - Blum, Stefan

AU - Boggild, Mike

AU - Boundy, Karyn

AU - Brew, Bruce J

AU - Brown, Matthew

AU - Brownlee, Wallace

AU - Butzkueven, Helmut

AU - Carroll, William

AU - Chen, Celia

AU - Coulthard, Alan

AU - Dale, Russell

AU - Das, Chandi

AU - Dear, Keith

AU - Fabis-Pedrini, Marzena

AU - Fulcher, David

AU - Gillis, David

AU - Hawke, Simon

AU - Heard, Robert

AU - Henderson, Andrew P D

AU - Heshmat, Saman

AU - Hodgkinson, Suzanne

AU - Jimenez-Sanchez, Sofia

AU - Killpatrick, Trevor

AU - King, John

AU - Kneebone, Chris

AU - Kornberg, Andrew

AU - Lechner-Scott, Jeannette

AU - Lin, Ming-Wei

AU - Lynch, Christopher

AU - Macdonell, Richard

AU - Mason, Deborah F

AU - McCombe, Pamela

AU - Pender, Michael

AU - Pereira, Jennifer

AU - Pollard, John

AU - Reddel, Stephen

AU - Shaw, Cameron

AU - Spies, Judith

AU - Stankovich, James

AU - Sutton, Ian

AU - Vucic, Steve

AU - Walsh, Michael

AU - Wong, Richard C

AU - Yiu, Eppie

AU - Barnett, Michael

AU - Kermode, Allan

AU - Marriott, Mark

AU - Parratt, John

AU - Slee, Mark

AU - Taylor, Bruce

AU - Willoughby, Ernest

AU - Wilson, Robert

AU - Vincent, Angela

AU - Broadly, Simon

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Objectives: We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry. Background: NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established. Methods: Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD. Testing for aquaporin 4 antibodies was undertaken in all suspected cases. From this group, cases were identified who fulfilled the 2015 Wingerchuk diagnostic criteria for NMOSD. A capture-recapture methodology was used to estimate incidence and prevalence, based on additional laboratory identified cases. Results: NMOSD was confirmed in 81/170 (48%) cases referred. Capture-recapture analysis gave an adjusted incidence estimate of 0.37 (95% CI 0.35 to 0.39) per million per year and a prevalence estimate for NMOSD of 0.70 (95% CI 0.61 to 0.78) per 100 000. NMOSD was three times more common in the Asian population (1.57 (95% CI 1.15 to 1.98) per 100 000) compared with the remainder of the population (0.57 (95% CI 0.50 to 0.65) per 100 000). The latitudinal gradient evident in multiple sclerosis was not seen in NMOSD. Conclusions: NMOSD incidence and prevalence in Australia and New Zealand are comparable with figures from other populations of largely European ancestry. We found NMOSD to be more common in the population with Asian ancestry.

AB - Objectives: We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry. Background: NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established. Methods: Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD. Testing for aquaporin 4 antibodies was undertaken in all suspected cases. From this group, cases were identified who fulfilled the 2015 Wingerchuk diagnostic criteria for NMOSD. A capture-recapture methodology was used to estimate incidence and prevalence, based on additional laboratory identified cases. Results: NMOSD was confirmed in 81/170 (48%) cases referred. Capture-recapture analysis gave an adjusted incidence estimate of 0.37 (95% CI 0.35 to 0.39) per million per year and a prevalence estimate for NMOSD of 0.70 (95% CI 0.61 to 0.78) per 100 000. NMOSD was three times more common in the Asian population (1.57 (95% CI 1.15 to 1.98) per 100 000) compared with the remainder of the population (0.57 (95% CI 0.50 to 0.65) per 100 000). The latitudinal gradient evident in multiple sclerosis was not seen in NMOSD. Conclusions: NMOSD incidence and prevalence in Australia and New Zealand are comparable with figures from other populations of largely European ancestry. We found NMOSD to be more common in the population with Asian ancestry.

KW - Ancestry

KW - Epidemiology

KW - Incidence

KW - Neuroimmunology

KW - Prevalence

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U2 - 10.1136/jnnp-2016-314839

DO - 10.1136/jnnp-2016-314839

M3 - Article

SN - 0022-3050

VL - 88

SP - 632

EP - 638

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

IS - 8

ER -

Incidence and prevalence of NMOSD in Australia and New Zealand

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