Increase in neuronal Jun immunoreactivity and epidermal NGF levels following UV exposure of rat skin

Frank Gillardon, Christoph Eschenfelde, Robert A. Rush, Manfred Zimmerman

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    23 Citations (Scopus)

    Abstract

    Effects of cutaneous ultraviolet (UV) irradiation on superficial nerve fibres are controversial. In the present study we demonstrate by electron microscopy that single high-dose UV exposure of rat skin results in membrane damage in peripheral nerves. Furthermore, a UV-induced accumulation of nerve growth factor (NGF) within the irradiated epidermis and a delayed increase in nuclear Jun immunoreactivity in dorsal root ganglion neurones were detected by immunohistochemistry. Our results suggest that UV-mediated alterations of axonal membranes leads to an activation of Jun transcription factor within affected neurones despite an increase in neurotrophic NGF within their innervation area.

    Original languageEnglish
    Pages (from-to)1322-1324
    Number of pages3
    JournalNeuroreport
    Volume6
    Issue number9
    DOIs
    Publication statusPublished - Jun 1995

    Keywords

    • Dorsal root ganglia
    • Electron microscopy
    • Epidermis
    • Immunohistochemistry
    • Jun
    • Nerve growth factor
    • Neurone damage
    • Ultraviolet radiation

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