Increase in neuronal Jun immunoreactivity and epidermal NGF levels following UV exposure of rat skin

Frank Gillardon, Christoph Eschenfelde, Robert A. Rush, Manfred Zimmerman

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    Effects of cutaneous ultraviolet (UV) irradiation on superficial nerve fibres are controversial. In the present study we demonstrate by electron microscopy that single high-dose UV exposure of rat skin results in membrane damage in peripheral nerves. Furthermore, a UV-induced accumulation of nerve growth factor (NGF) within the irradiated epidermis and a delayed increase in nuclear Jun immunoreactivity in dorsal root ganglion neurones were detected by immunohistochemistry. Our results suggest that UV-mediated alterations of axonal membranes leads to an activation of Jun transcription factor within affected neurones despite an increase in neurotrophic NGF within their innervation area.

    Original languageEnglish
    Pages (from-to)1322-1324
    Number of pages3
    JournalNeuroreport
    Volume6
    Issue number9
    DOIs
    Publication statusPublished - Jun 1995

    Keywords

    • Dorsal root ganglia
    • Electron microscopy
    • Epidermis
    • Immunohistochemistry
    • Jun
    • Nerve growth factor
    • Neurone damage
    • Ultraviolet radiation

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