Increase in neuronal Jun immunoreactivity and epidermal NGF levels following UV exposure of rat skin

Frank Gillardon; Christoph Eschenfelde; Robert A. Rush; Manfred Zimmerman

doi:10.1097/00001756-199506090-00023

Increase in neuronal Jun immunoreactivity and epidermal NGF levels following UV exposure of rat skin

Frank Gillardon, Christoph Eschenfelde, Robert A. Rush, Manfred Zimmerman

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Effects of cutaneous ultraviolet (UV) irradiation on superficial nerve fibres are controversial. In the present study we demonstrate by electron microscopy that single high-dose UV exposure of rat skin results in membrane damage in peripheral nerves. Furthermore, a UV-induced accumulation of nerve growth factor (NGF) within the irradiated epidermis and a delayed increase in nuclear Jun immunoreactivity in dorsal root ganglion neurones were detected by immunohistochemistry. Our results suggest that UV-mediated alterations of axonal membranes leads to an activation of Jun transcription factor within affected neurones despite an increase in neurotrophic NGF within their innervation area.

Original language	English
Pages (from-to)	1322-1324
Number of pages	3
Journal	Neuroreport
Volume	6
Issue number	9
DOIs	https://doi.org/10.1097/00001756-199506090-00023
Publication status	Published - Jun 1995

Keywords

Dorsal root ganglia
Electron microscopy
Epidermis
Immunohistochemistry
Jun
Nerve growth factor
Neurone damage
Ultraviolet radiation

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title = "Increase in neuronal Jun immunoreactivity and epidermal NGF levels following UV exposure of rat skin",

abstract = "Effects of cutaneous ultraviolet (UV) irradiation on superficial nerve fibres are controversial. In the present study we demonstrate by electron microscopy that single high-dose UV exposure of rat skin results in membrane damage in peripheral nerves. Furthermore, a UV-induced accumulation of nerve growth factor (NGF) within the irradiated epidermis and a delayed increase in nuclear Jun immunoreactivity in dorsal root ganglion neurones were detected by immunohistochemistry. Our results suggest that UV-mediated alterations of axonal membranes leads to an activation of Jun transcription factor within affected neurones despite an increase in neurotrophic NGF within their innervation area.",

keywords = "Dorsal root ganglia, Electron microscopy, Epidermis, Immunohistochemistry, Jun, Nerve growth factor, Neurone damage, Ultraviolet radiation",

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AU - Gillardon, Frank

AU - Eschenfelde, Christoph

AU - Rush, Robert A.

AU - Zimmerman, Manfred

PY - 1995/6

Y1 - 1995/6

N2 - Effects of cutaneous ultraviolet (UV) irradiation on superficial nerve fibres are controversial. In the present study we demonstrate by electron microscopy that single high-dose UV exposure of rat skin results in membrane damage in peripheral nerves. Furthermore, a UV-induced accumulation of nerve growth factor (NGF) within the irradiated epidermis and a delayed increase in nuclear Jun immunoreactivity in dorsal root ganglion neurones were detected by immunohistochemistry. Our results suggest that UV-mediated alterations of axonal membranes leads to an activation of Jun transcription factor within affected neurones despite an increase in neurotrophic NGF within their innervation area.

AB - Effects of cutaneous ultraviolet (UV) irradiation on superficial nerve fibres are controversial. In the present study we demonstrate by electron microscopy that single high-dose UV exposure of rat skin results in membrane damage in peripheral nerves. Furthermore, a UV-induced accumulation of nerve growth factor (NGF) within the irradiated epidermis and a delayed increase in nuclear Jun immunoreactivity in dorsal root ganglion neurones were detected by immunohistochemistry. Our results suggest that UV-mediated alterations of axonal membranes leads to an activation of Jun transcription factor within affected neurones despite an increase in neurotrophic NGF within their innervation area.

KW - Dorsal root ganglia

KW - Electron microscopy

KW - Epidermis

KW - Immunohistochemistry

KW - Jun

KW - Nerve growth factor

KW - Neurone damage

KW - Ultraviolet radiation

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AN - SCOPUS:0028979731

SN - 1473-558X

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SP - 1322

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JO - Neuroreport

JF - Neuroreport

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ER -

Increase in neuronal Jun immunoreactivity and epidermal NGF levels following UV exposure of rat skin

Abstract

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