TY - JOUR
T1 - Increased BMI ‘alone’ does not negatively influence sperm function - a retrospective analysis of men attending fertility treatment with corresponding liver function results
AU - McPherson, Nicole O.
AU - Tremellen, Kelton
PY - 2020/3
Y1 - 2020/3
N2 - Does increased body mass index (BMI) without an underlying metabolic issue negatively influence semen quality? Proof of concept we conducted retrospective data analysis of men (N = 84) undergoing assisted reproductive technology, who had liver function testing with fasted glucose concentrations and corresponding hormone profile (testosterone, LH, FSH and prolactin) and semen analysis. Sperm count and total concentration were only reduced in metabolically unhealthy overweight/obese men. Serum GTT was the biggest predictor of Normozoospermia and Oligospermia, with BMI having no effect. Increased BMI without an underlying metabolic condition (in particular signs of NAFLD) has no influence on semen quality.
AB - Does increased body mass index (BMI) without an underlying metabolic issue negatively influence semen quality? Proof of concept we conducted retrospective data analysis of men (N = 84) undergoing assisted reproductive technology, who had liver function testing with fasted glucose concentrations and corresponding hormone profile (testosterone, LH, FSH and prolactin) and semen analysis. Sperm count and total concentration were only reduced in metabolically unhealthy overweight/obese men. Serum GTT was the biggest predictor of Normozoospermia and Oligospermia, with BMI having no effect. Increased BMI without an underlying metabolic condition (in particular signs of NAFLD) has no influence on semen quality.
KW - Infertility
KW - Metabolic syndrome
KW - Obesity
KW - Semen
UR - http://www.scopus.com/inward/record.url?scp=85083313302&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1088964
U2 - 10.1016/j.orcp.2020.03.003
DO - 10.1016/j.orcp.2020.03.003
M3 - Article
C2 - 32321679
AN - SCOPUS:85083313302
VL - 14
SP - 164
EP - 167
JO - Obesity Research and Clinical Practice
JF - Obesity Research and Clinical Practice
SN - 1871-403X
IS - 2
ER -