Increased brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia and spinal cord following peripheral inflammation

Hee Jung Cho, Jeong Ki Kim, Xin Fu Zhou, Robert A. Rush

    Research output: Contribution to journalArticle

    128 Citations (Scopus)

    Abstract

    Our recent study showed that peripheral inflammation induced an increased expression of brain-derived neurotrophic factor (BDNF) mRNA which was mediated by nerve growth factor (NGF) in the dorsal root ganglion (DRG). In the present study, we evaluated the change of BDNF immunoreactivity in the DRG and spinal cord following peripheral inflammation by means of immunohistochemistry. Significant increases in the percentage of BDNF- immunoreactive (IR) neuron profiles in the L5 DRG and marked elevation in the expression of BDNF-IR terminals in the spinal dorsal horn were observed following peripheral tissue inflammation produced by an intraplantar injection of Freund's adjuvant into the rat paws. These findings suggest that peripheral tissue inflammation induces an increased BDNF synthesis in the DRG and an elevated anterograde transport of BDNF to the spinal dorsal horn. The functional role of this increased BDNF was discussed briefly.

    Original languageEnglish
    Pages (from-to)269-272
    Number of pages4
    JournalBrain Research
    Volume764
    Issue number1-2
    DOIs
    Publication statusPublished - 1 Aug 1997

    Keywords

    • Brain-derived neurotrophic factor
    • Dorsal root ganglion
    • Immunohistochem-istry
    • Nerve growth factor
    • Pain
    • Peripheral inflammation
    • Spinal cord

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