Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme

Min Zi Deng; Wan Xia He; Ya Tan; Hai Long Han; Xiang You Hu; Kun Xia; Zhuohua Zhang; Ri Qiang Yan

doi:10.1074/jbc.M113.480079

Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme

Min Zi Deng, Wan Xia He, Ya Tan, Hai Long Han, Xiang You Hu, Kun Xia, Zhuohua Zhang, Ri Qiang Yan

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Background: Axonal transport of BACE1 and the regulation of BACE1 synaptic localization remain to be fully characterized. Results: Colocalization of BACE1 with synaptophysin was reduced by overexpression of RTN3. This reduction was due to reduced BACE1 axonal transport. Conclusion: Increased interaction of RTN3 with BACE1 in the soma impacts axonal transport of BACE1. Significance: Changes of BACE1 synaptic localization potentially alter synaptic A generation and amyloid deposition.

Original language	English
Pages (from-to)	30236-30245
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M113.480079
Publication status	Published - 18 Oct 2013

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title = "Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme",

abstract = "Background: Axonal transport of BACE1 and the regulation of BACE1 synaptic localization remain to be fully characterized. Results: Colocalization of BACE1 with synaptophysin was reduced by overexpression of RTN3. This reduction was due to reduced BACE1 axonal transport. Conclusion: Increased interaction of RTN3 with BACE1 in the soma impacts axonal transport of BACE1. Significance: Changes of BACE1 synaptic localization potentially alter synaptic A generation and amyloid deposition.",

author = "Deng, {Min Zi} and He, {Wan Xia} and Ya Tan and Han, {Hai Long} and Hu, {Xiang You} and Kun Xia and Zhuohua Zhang and Yan, {Ri Qiang}",

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doi = "10.1074/jbc.M113.480079",

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journal = "Journal of Biological Chemistry",

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publisher = "American Society for Biochemistry and Molecular Biology",

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Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme. / Deng, Min Zi; He, Wan Xia; Tan, Ya; Han, Hai Long; Hu, Xiang You; Xia, Kun; Zhang, Zhuohua; Yan, Ri Qiang.

In: Journal of Biological Chemistry, Vol. 288, No. 42, 18.10.2013, p. 30236-30245.

Research output: Contribution to journal › Article › peer-review

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T1 - Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme

AU - Deng, Min Zi

AU - He, Wan Xia

AU - Tan, Ya

AU - Han, Hai Long

AU - Hu, Xiang You

AU - Xia, Kun

AU - Zhang, Zhuohua

AU - Yan, Ri Qiang

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background: Axonal transport of BACE1 and the regulation of BACE1 synaptic localization remain to be fully characterized. Results: Colocalization of BACE1 with synaptophysin was reduced by overexpression of RTN3. This reduction was due to reduced BACE1 axonal transport. Conclusion: Increased interaction of RTN3 with BACE1 in the soma impacts axonal transport of BACE1. Significance: Changes of BACE1 synaptic localization potentially alter synaptic A generation and amyloid deposition.

AB - Background: Axonal transport of BACE1 and the regulation of BACE1 synaptic localization remain to be fully characterized. Results: Colocalization of BACE1 with synaptophysin was reduced by overexpression of RTN3. This reduction was due to reduced BACE1 axonal transport. Conclusion: Increased interaction of RTN3 with BACE1 in the soma impacts axonal transport of BACE1. Significance: Changes of BACE1 synaptic localization potentially alter synaptic A generation and amyloid deposition.

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