Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme

Min Zi Deng; Wan Xia He; Ya Tan; Hai Long Han; Xiang You Hu; Kun Xia; Zhuohua Zhang; Ri Qiang Yan

doi:10.1074/jbc.M113.480079

Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme

Min Zi Deng, Wan Xia He, Ya Tan, Hai Long Han, Xiang You Hu, Kun Xia, Zhuohua Zhang, Ri Qiang Yan

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Background: Axonal transport of BACE1 and the regulation of BACE1 synaptic localization remain to be fully characterized. Results: Colocalization of BACE1 with synaptophysin was reduced by overexpression of RTN3. This reduction was due to reduced BACE1 axonal transport. Conclusion: Increased interaction of RTN3 with BACE1 in the soma impacts axonal transport of BACE1. Significance: Changes of BACE1 synaptic localization potentially alter synaptic A generation and amyloid deposition.

Original language	English
Pages (from-to)	30236-30245
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M113.480079
Publication status	Published - 18 Oct 2013

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title = "Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme",

abstract = "Background: Axonal transport of BACE1 and the regulation of BACE1 synaptic localization remain to be fully characterized. Results: Colocalization of BACE1 with synaptophysin was reduced by overexpression of RTN3. This reduction was due to reduced BACE1 axonal transport. Conclusion: Increased interaction of RTN3 with BACE1 in the soma impacts axonal transport of BACE1. Significance: Changes of BACE1 synaptic localization potentially alter synaptic A generation and amyloid deposition.",

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T1 - Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme

AU - Deng, Min Zi

AU - He, Wan Xia

AU - Tan, Ya

AU - Han, Hai Long

AU - Hu, Xiang You

AU - Xia, Kun

AU - Zhang, Zhuohua

AU - Yan, Ri Qiang

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background: Axonal transport of BACE1 and the regulation of BACE1 synaptic localization remain to be fully characterized. Results: Colocalization of BACE1 with synaptophysin was reduced by overexpression of RTN3. This reduction was due to reduced BACE1 axonal transport. Conclusion: Increased interaction of RTN3 with BACE1 in the soma impacts axonal transport of BACE1. Significance: Changes of BACE1 synaptic localization potentially alter synaptic A generation and amyloid deposition.

AB - Background: Axonal transport of BACE1 and the regulation of BACE1 synaptic localization remain to be fully characterized. Results: Colocalization of BACE1 with synaptophysin was reduced by overexpression of RTN3. This reduction was due to reduced BACE1 axonal transport. Conclusion: Increased interaction of RTN3 with BACE1 in the soma impacts axonal transport of BACE1. Significance: Changes of BACE1 synaptic localization potentially alter synaptic A generation and amyloid deposition.

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U2 - 10.1074/jbc.M113.480079

DO - 10.1074/jbc.M113.480079

M3 - Article

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EP - 30245

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 42

ER -

Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme

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