Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme

Min Zi Deng, Wan Xia He, Ya Tan, Hai Long Han, Xiang You Hu, Kun Xia, Zhuohua Zhang, Ri Qiang Yan

    Research output: Contribution to journalArticlepeer-review

    36 Citations (Scopus)

    Abstract

    Background: Axonal transport of BACE1 and the regulation of BACE1 synaptic localization remain to be fully characterized. Results: Colocalization of BACE1 with synaptophysin was reduced by overexpression of RTN3. This reduction was due to reduced BACE1 axonal transport. Conclusion: Increased interaction of RTN3 with BACE1 in the soma impacts axonal transport of BACE1. Significance: Changes of BACE1 synaptic localization potentially alter synaptic A generation and amyloid deposition.

    Original languageEnglish
    Pages (from-to)30236-30245
    Number of pages10
    JournalJournal of Biological Chemistry
    Volume288
    Issue number42
    DOIs
    Publication statusPublished - 18 Oct 2013

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