Increased kynurenine plasma concentrations and kynurenine-tryptophan ratio in mild-to-moderate chronic obstructive pulmonary disease patients

Angelo Zinellu, Alessandro Fois, Elisabetta Zinellu, Elisabetta Sotgiu, Salvatore Sotgia, Dionigia Arru, Arduino Mangoni, Ciriaco Carru, Pietro Pirina

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Aim: Since an increase in kynurenine (Kyn) plasma concentrations has been proposed as marker of immune system activation, we studied the associations between the Kyn levels and presence and severity of chronic obstructive pulmonary disease (COPD). Methods & results: Plasma Kyn, tryptophan (Trp) and Kyn/Trp ratio were measured in 43 COPD patients with clinically defined mild (n = 29) or moderate (n = 14) disease and 43 age- and sex-matched healthy controls. When compared with controls, COPD patients had significantly higher plasma Kyn concentrations and Kyn/Trp ratios. In multiple logistic regression analysis, after adjusting for clinical and demographic confounders, the Kyn/Trp ratio was independently associated with COPD severity. Discussion & conclusion: Kyn and Kyn/Trp ratio might represent a new, sensitive, biomarker of systemic inflammation in COPD patients.

    Original languageEnglish
    Pages (from-to)229-237
    Number of pages9
    JournalBiomarkers in Medicine
    Volume12
    Issue number3
    DOIs
    Publication statusPublished - Mar 2018

    Keywords

    • chronic obstructive pulmonary disease
    • inflammation
    • kynurenine
    • oxidative stress
    • tryptophan

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