Increased number of PNMT-immunofluorescent nerve cell bodies in the medulla oblongata of stroke-prone hypertensive rats

P. R.C. Howe; W. Lovenberg; J. P. Chalmers

doi:10.1016/0006-8993(81)90724-1

Increased number of PNMT-immunofluorescent nerve cell bodies in the medulla oblongata of stroke-prone hypertensive rats

P. R.C. Howe, W. Lovenberg, J. P. Chalmers

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

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Abstract

An antiserum to bovine adrenal PNMT was used to identify PNMT-containing nerve cell bodies in the medulla oblongata of 4-week-old normotensive Wistar-Kyoto rats and stroke-prone spontaneously hypertensive rats. The regional distribution of PNMT cells and the total number of PNMT cell profiles in tranverse sections of the medulla were examined in each of the two strains. While there was no significant difference in the pattern of distribution of the cells, both the number of PNMT cell profiles per section and the total number seen in all sections of the medulla were significantly higher in the hypertensive rats. The increase in counts of PNMT cell profiles in the medulla suggests that there is a genetic difference in the number of central adrenaline neurons in these hypertensive rats. This is supported by the finding of similar increases of PNMT enzyme activity in the medulla of both stroke-prone spontaneously hypertensive rats and spontaneously hypertensive rats compared with Wistar-Kyoto rats.

Original language	English
Pages (from-to)	123-130
Number of pages	8
Journal	Brain Research
Volume	205
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(81)90724-1
Publication status	Published - 26 Jan 1981

Keywords

hypertensive rats
immunofluorescence
PNMT cell bodies
stroke

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title = "Increased number of PNMT-immunofluorescent nerve cell bodies in the medulla oblongata of stroke-prone hypertensive rats",

abstract = "An antiserum to bovine adrenal PNMT was used to identify PNMT-containing nerve cell bodies in the medulla oblongata of 4-week-old normotensive Wistar-Kyoto rats and stroke-prone spontaneously hypertensive rats. The regional distribution of PNMT cells and the total number of PNMT cell profiles in tranverse sections of the medulla were examined in each of the two strains. While there was no significant difference in the pattern of distribution of the cells, both the number of PNMT cell profiles per section and the total number seen in all sections of the medulla were significantly higher in the hypertensive rats. The increase in counts of PNMT cell profiles in the medulla suggests that there is a genetic difference in the number of central adrenaline neurons in these hypertensive rats. This is supported by the finding of similar increases of PNMT enzyme activity in the medulla of both stroke-prone spontaneously hypertensive rats and spontaneously hypertensive rats compared with Wistar-Kyoto rats.",

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AU - Lovenberg, W.

AU - Chalmers, J. P.

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N2 - An antiserum to bovine adrenal PNMT was used to identify PNMT-containing nerve cell bodies in the medulla oblongata of 4-week-old normotensive Wistar-Kyoto rats and stroke-prone spontaneously hypertensive rats. The regional distribution of PNMT cells and the total number of PNMT cell profiles in tranverse sections of the medulla were examined in each of the two strains. While there was no significant difference in the pattern of distribution of the cells, both the number of PNMT cell profiles per section and the total number seen in all sections of the medulla were significantly higher in the hypertensive rats. The increase in counts of PNMT cell profiles in the medulla suggests that there is a genetic difference in the number of central adrenaline neurons in these hypertensive rats. This is supported by the finding of similar increases of PNMT enzyme activity in the medulla of both stroke-prone spontaneously hypertensive rats and spontaneously hypertensive rats compared with Wistar-Kyoto rats.

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Increased number of PNMT-immunofluorescent nerve cell bodies in the medulla oblongata of stroke-prone hypertensive rats

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Keywords

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