Increased plasma Brain-Derived Neurotrophic Factor (BDNF)levels in females with schizophrenia

Cynthia Shannon Shannon Weickert, Cynthia H. Lee, Rhoshel Lenroot, Jason M. Bruggemann, Cherrie Galletly, Dennis T Liu, Ryan P. Balzan, Anilkumar K. Pillai, Peter Francis Buckley, Thomas W. Weickert

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Abstract

Brain-Derived Neurotrophic Factor (BDNF) acts as a critical regulator of synaptogenesis and synaptic plasticity. Sex differences have been demonstrated in many aspects of schizophrenia. This study tested for sex-specific differences in peripheral BDNF levels in people with schizophrenia and healthy controls. We measured circulating plasma BDNF levels in 95 people with schizophrenia and 80 healthy controls. Plasma BDNF levels were significantly elevated in females with schizophrenia compared to males with schizophrenia and to female healthy controls. These results suggest that sex differences in peripheral BDNF levels may contribute to other sex related differences in schizophrenia.

Original languageEnglish
Pages (from-to)212-217
Number of pages6
JournalSCHIZOPHRENIA RESEARCH
Volume209
DOIs
Publication statusPublished - Jul 2019

Keywords

  • BDNF
  • Schizophrenia
  • Sex differences

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    Shannon Weickert, C. S., Lee, C. H., Lenroot, R., Bruggemann, J. M., Galletly, C., Liu, D. T., Balzan, R. P., Pillai, A. K., Buckley, P. F., & Weickert, T. W. (2019). Increased plasma Brain-Derived Neurotrophic Factor (BDNF)levels in females with schizophrenia. SCHIZOPHRENIA RESEARCH, 209, 212-217. https://doi.org/10.1016/j.schres.2019.04.015