Increased plasma Brain-Derived Neurotrophic Factor (BDNF)levels in females with schizophrenia

Cynthia Shannon Shannon Weickert; Cynthia H. Lee; Rhoshel Lenroot; Jason M. Bruggemann; Cherrie Galletly; Dennis T Liu; Ryan P. Balzan; Anilkumar K. Pillai; Peter Francis Buckley; Thomas W. Weickert

doi:10.1016/j.schres.2019.04.015

Increased plasma Brain-Derived Neurotrophic Factor (BDNF)levels in females with schizophrenia

Cynthia Shannon Shannon Weickert, Cynthia H. Lee, Rhoshel Lenroot, Jason M. Bruggemann, Cherrie Galletly, Dennis T Liu, Ryan P. Balzan, Anilkumar K. Pillai, Peter Francis Buckley, Thomas W. Weickert

College of Education, Psychology and Social Work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Brain-Derived Neurotrophic Factor (BDNF) acts as a critical regulator of synaptogenesis and synaptic plasticity. Sex differences have been demonstrated in many aspects of schizophrenia. This study tested for sex-specific differences in peripheral BDNF levels in people with schizophrenia and healthy controls. We measured circulating plasma BDNF levels in 95 people with schizophrenia and 80 healthy controls. Plasma BDNF levels were significantly elevated in females with schizophrenia compared to males with schizophrenia and to female healthy controls. These results suggest that sex differences in peripheral BDNF levels may contribute to other sex related differences in schizophrenia.

Original language	English
Pages (from-to)	212-217
Number of pages	6
Journal	SCHIZOPHRENIA RESEARCH
Volume	209
DOIs	https://doi.org/10.1016/j.schres.2019.04.015
Publication status	Published - Jul 2019

Keywords

BDNF
Schizophrenia
Sex differences

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10.1016/j.schres.2019.04.015

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title = "Increased plasma Brain-Derived Neurotrophic Factor (BDNF)levels in females with schizophrenia",

abstract = "Brain-Derived Neurotrophic Factor (BDNF) acts as a critical regulator of synaptogenesis and synaptic plasticity. Sex differences have been demonstrated in many aspects of schizophrenia. This study tested for sex-specific differences in peripheral BDNF levels in people with schizophrenia and healthy controls. We measured circulating plasma BDNF levels in 95 people with schizophrenia and 80 healthy controls. Plasma BDNF levels were significantly elevated in females with schizophrenia compared to males with schizophrenia and to female healthy controls. These results suggest that sex differences in peripheral BDNF levels may contribute to other sex related differences in schizophrenia.",

keywords = "BDNF, Schizophrenia, Sex differences",

author = "{Shannon Weickert}, {Cynthia Shannon} and Lee, {Cynthia H.} and Rhoshel Lenroot and Bruggemann, {Jason M.} and Cherrie Galletly and Liu, {Dennis T} and Balzan, {Ryan P.} and Pillai, {Anilkumar K.} and Buckley, {Peter Francis} and Weickert, {Thomas W.}",

year = "2019",

month = jul,

doi = "10.1016/j.schres.2019.04.015",

language = "English",

volume = "209",

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T1 - Increased plasma Brain-Derived Neurotrophic Factor (BDNF)levels in females with schizophrenia

AU - Shannon Weickert, Cynthia Shannon

AU - Lee, Cynthia H.

AU - Lenroot, Rhoshel

AU - Bruggemann, Jason M.

AU - Galletly, Cherrie

AU - Liu, Dennis T

AU - Balzan, Ryan P.

AU - Pillai, Anilkumar K.

AU - Buckley, Peter Francis

AU - Weickert, Thomas W.

PY - 2019/7

Y1 - 2019/7

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AB - Brain-Derived Neurotrophic Factor (BDNF) acts as a critical regulator of synaptogenesis and synaptic plasticity. Sex differences have been demonstrated in many aspects of schizophrenia. This study tested for sex-specific differences in peripheral BDNF levels in people with schizophrenia and healthy controls. We measured circulating plasma BDNF levels in 95 people with schizophrenia and 80 healthy controls. Plasma BDNF levels were significantly elevated in females with schizophrenia compared to males with schizophrenia and to female healthy controls. These results suggest that sex differences in peripheral BDNF levels may contribute to other sex related differences in schizophrenia.

KW - BDNF

KW - Schizophrenia

KW - Sex differences

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JO - SCHIZOPHRENIA RESEARCH

JF - SCHIZOPHRENIA RESEARCH

ER -

Increased plasma Brain-Derived Neurotrophic Factor (BDNF)levels in females with schizophrenia

Abstract

Keywords

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