Increased substance P immunoreactivity and edema formation following reversible ischemic stroke

R. J. Turner, P. C. Blumbergs, N. R. Sims, S. C. Helps, K. M. Rodgers, R. Vink

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

43 Citations (Scopus)


Previous results from our laboratory have shown that neurogenic inflammation is associated with edema formation after traumatic brain injury (TBI). This neurogenic inflammation was characterized by increased substance P (SP) immunoreactivity and could be attenuated with administration of SP antagonists with a resultant decrease in edema formation. Few studies have examined whether neurogenic inflammation, as identified by increased SP immunoreactivity, occurs after stroke and its potential role in edema formation. The present study examines SP immunoreactivity and edema formation following stroke. Experimental stroke was induced in halothane anaesthetized male Sprague-Dawley rats using a reversible thread model of middle cerebral artery occlusion. Increased SP immunoreactivity at 24 hours relative to the non-infarcted hemisphere was observed in perivascular, neuronal, and glial tissue, and within the penumbra of the infarcted hemisphere. It was not as apparent in the infarct core. This increased SP immunoreactivity was associated with edema formation. We conclude that neurogenic inflammation, as reflected by increased SP immunoreactivity, occurs following experimental stroke, and that this may be associated with edema formation. As such, inhibition of neurogenic inflammation may represent a novel therapeutic target for the treatment of edema following reversible, ischemic stroke.

Original languageEnglish
Title of host publicationBrain Edema XIII
Number of pages4
ISBN (Print)9783211307120
Publication statusPublished - 2006

Publication series

NameActa Neurochirurgica, Supplementum
ISSN (Print)0065-1419

Bibliographical note

Copyright 2018 Elsevier B.V., All rights reserved.


  • edema
  • inflammation
  • Ischemia
  • neuropeptides


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