Increases in plasma neuropeptide Y concentrations during sympathetic activation in man

M. J. Morris, A. E. Russell, V. Kapoor, M. D. Cain, J. M. Elliott, M. J. West, L. M.H. Wing, J. P. Chalmers

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Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons. In order to test the hypothesis that NPY may be released along with catecholamines by activation of the sympathoadrenal system we measured plasma NPY-like immunoreactivity (NPY-LI) concentrations during cold pressor test, head up tilt and bicycle exercise in healthy volunteers. All 3 manoeuvres resulted in elevation of blood pressure, heart rate and plasma noradrenaline and adrenaline concentrations. These were accompanied by increases in plasma NPY-LI concentrations on cold pressor test and exercise, but not with head up tilt. The increases in both NPY-LI and catecholamines were greatest with exercise. These findings suggest that NPY is released at the same time as noradrenaline when sympathetic noradrenergic nerves are activated.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalJournal of the Autonomic Nervous System
Issue number2
Publication statusPublished - Oct 1986
Externally publishedYes


  • Cold pressor test
  • Exercise
  • Plasma adrenaline
  • Plasma neuropeptide Y
  • Plasma noradrenaline
  • Tilt


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