Indomethacin for renal impairment in neonatal Bartter's syndrome: Letter to the Editor

Sir - Bartter’s syndrome causes muscle weakness, polyuria, polydipsia, failure to thrive, delayed growth, hypokalaemia, metabolic alkalosis, hyper-reninaemia, hyperaldosteronism, increased urinary prostaglandin excretion, and renal impairment. Polyhydramnios with hypercalciuria and nephrocalcinosis are features of the neonatal form of the condition. Indomethacin promotes catch-up growth and reverses nephrocalcinosis. We report the effect of indomethacin on glomerular function in a 5-year-old girl with Bartter’s syndrome.