Abstract
Background and Objectives: Inflammation has been associated with reduced appetite and body composition changes in
populations with established diseases. However, it is not known if an association exists between appetite, body composition and
inflammation in healthy people. Design: To explore associations of appetite with markers of inflammation and body composition,
data from the Cytokines, Adiposity, Sarcopenia and Ageing (CASA) study was analysed. Setting: Western suburbs, Adelaide,
Australia. Participants: 180, population representative, healthy participants, aged 18 – 82 years, were studied. Measurements: Body
composition was measured by both Dual X-ray absorbiometry (DXA) and bioelectrical impedance analysis (BIA). Appetite was
assessed by the Simplified Nutritional Appetite Questionnaire (SNAQ). Circulating cytokine concentrations were measured.
Results: Multiple regression analysis showed appetite scores were increased in non-smokers (P = 0.031) and men (P = 0.024),
negatively associated with serum levels of the pro-inflammatory IL-1β (β coefficient = - 0.379, P = 0.007), and positively associated
with serum levels of the anti-inflammatory cytokine IL-10 (β coefficient = 0.25, P = 0.010). There was no association between
appetite and body composition. Conclusions: Appetite loss may reflect background inflammation even in apparently healthy people,
and probably occurs before consequent changes in body composition. Further explorations of longer term appetite changes with
respect to inflammation and body composition changes are needed.
populations with established diseases. However, it is not known if an association exists between appetite, body composition and
inflammation in healthy people. Design: To explore associations of appetite with markers of inflammation and body composition,
data from the Cytokines, Adiposity, Sarcopenia and Ageing (CASA) study was analysed. Setting: Western suburbs, Adelaide,
Australia. Participants: 180, population representative, healthy participants, aged 18 – 82 years, were studied. Measurements: Body
composition was measured by both Dual X-ray absorbiometry (DXA) and bioelectrical impedance analysis (BIA). Appetite was
assessed by the Simplified Nutritional Appetite Questionnaire (SNAQ). Circulating cytokine concentrations were measured.
Results: Multiple regression analysis showed appetite scores were increased in non-smokers (P = 0.031) and men (P = 0.024),
negatively associated with serum levels of the pro-inflammatory IL-1β (β coefficient = - 0.379, P = 0.007), and positively associated
with serum levels of the anti-inflammatory cytokine IL-10 (β coefficient = 0.25, P = 0.010). There was no association between
appetite and body composition. Conclusions: Appetite loss may reflect background inflammation even in apparently healthy people,
and probably occurs before consequent changes in body composition. Further explorations of longer term appetite changes with
respect to inflammation and body composition changes are needed.
| Original language | English |
|---|---|
| Pages (from-to) | 41-43 |
| Number of pages | 3 |
| Journal | Journal of Aging Research & Clinical Practice |
| Volume | 1 |
| Issue number | 1 |
| Publication status | Published - 2012 |
Bibliographical note
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Cite this
Dent, E., Yu, S., Visvanathan, R., Piantadosi, C., Adams, R., Lange, K., & Chapman, I. (2012). Inflammatory cytokines and appetite in healthy people. Journal of Aging Research & Clinical Practice, 1(1), 41-43.