Inflammatory cytokines and appetite in healthy people

E Dent, S Yu, R Visvanathan, C Piantadosi, R Adams, K Lange, I Chapman

Research output: Contribution to journalArticle

2 Downloads (Pure)

Abstract

Background and Objectives: Inflammation has been associated with reduced appetite and body composition changes in
populations with established diseases. However, it is not known if an association exists between appetite, body composition and
inflammation in healthy people. Design: To explore associations of appetite with markers of inflammation and body composition,
data from the Cytokines, Adiposity, Sarcopenia and Ageing (CASA) study was analysed. Setting: Western suburbs, Adelaide,
Australia. Participants: 180, population representative, healthy participants, aged 18 – 82 years, were studied. Measurements: Body
composition was measured by both Dual X-ray absorbiometry (DXA) and bioelectrical impedance analysis (BIA). Appetite was
assessed by the Simplified Nutritional Appetite Questionnaire (SNAQ). Circulating cytokine concentrations were measured.
Results: Multiple regression analysis showed appetite scores were increased in non-smokers (P = 0.031) and men (P = 0.024),
negatively associated with serum levels of the pro-inflammatory IL-1β (β coefficient = - 0.379, P = 0.007), and positively associated
with serum levels of the anti-inflammatory cytokine IL-10 (β coefficient = 0.25, P = 0.010). There was no association between
appetite and body composition. Conclusions: Appetite loss may reflect background inflammation even in apparently healthy people,
and probably occurs before consequent changes in body composition. Further explorations of longer term appetite changes with
respect to inflammation and body composition changes are needed.
Original languageEnglish
Pages (from-to)41-43
Number of pages3
JournalJournal of Aging Research & Clinical Practice
Volume1
Issue number1
Publication statusPublished - 2012

Bibliographical note

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Fingerprint Dive into the research topics of 'Inflammatory cytokines and appetite in healthy people'. Together they form a unique fingerprint.

  • Cite this

    Dent, E., Yu, S., Visvanathan, R., Piantadosi, C., Adams, R., Lange, K., & Chapman, I. (2012). Inflammatory cytokines and appetite in healthy people. Journal of Aging Research & Clinical Practice, 1(1), 41-43.