Inflammatory monomorphic undifferentiated sarcoma with distinct clinical and pathological features: A 'new' entity?

Zhe Wang, Gaosheng Huang, Qingguo Yan, Lu Wang, J Zhu, Yi Lu, Peifeng Li, Hong Cheng, M Ma, Bruce Walkerz, Philip Allen

    Research output: Contribution to journalReview articlepeer-review

    3 Citations (Scopus)


    Aim: To describe two patients with a highly aggressive, apparently 'new' and rare soft tissue and bone malignancy of childhood and early adult life that we have named inflammatory monomorphic undifferentiated sarcoma. Methods and results: Two histologically identical tumours located in the proximal humerus and the anterior chest wall of males aged 6 and 31 presented as solitary, painful, tender, necrotising, masses, associated with fever, leukocytosis and negative microbiological cultures. The extensively necrotic resected tumours consisted of large, monomorphic epithelioid cells with vesicular nuclei, prominent eosinophilic nucleoli, and abundant eosinophilic cytoplasm surrounded by numerous neutrophils and eosinophils which formed sterile microabscesses. Immunohistochemical and ultrastructural studies revealed no specific differentiation. Both tumours were very aggressive, with early local recurrence, metastasis to regional and distant lymph nodes and viscera, and no response to several different chemotherapeutic regimens. Conclusion: A careful review of the literature led us to believe that inflammatory monomorphic undifferentiated sarcoma may represent a rare and distinct clinicopathological entity that does not appear to have been previously described.

    Original languageEnglish
    Pages (from-to)48-53
    Number of pages6
    Issue number1
    Publication statusPublished - Jan 2011


    • Inflammatory monomorphic undifferentiated sarcoma
    • Suppurative inflammation


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