Influence of endometriosis on assisted reproductive technology outcomes: A systematic review and meta-analysis

Kelton Tremellen, Vamsee Thalluri

    Research output: Contribution to journalLetterpeer-review

    2 Citations (Scopus)

    Abstract

    We read with interest the systematic review by Hamdan and colleagues1 examining the effects of endometriosis on in vitro fertilization (IVF) outcomes. The authors conclude that minor degrees of endometriosis have no effect on IVF pregnancy outcomes but that more severe grades of endometriosis appear to diminish IVF live birth rates. Although we agree with this conclusion, we feel that the discussion is incomplete because it fails to mention the possible role of adenomyosis.

    Adenomyosis recently has been linked with an increase in early pregnancy loss and a significant reduction in clinical pregnancy rates during IVF treatment.2 Furthermore, studies have shown that adenomyosis is very commonly present in women with severe endometriosis3 and that adenomyosis is associated with multiple alterations in endometrial function.4 Therefore, we believe that the reported reduction in IVF live birth rates seen in women with severe endometriosis is most likely related to the negative effects of adenomyosis on implantation.
    Original languageEnglish
    Pages (from-to)1498-1499
    Number of pages2
    JournalObstetrics and Gynecology
    Volume125
    Issue number6
    DOIs
    Publication statusPublished - 28 Jun 2015

    Keywords

    • Endometriosis
    • assisted reproductive technology
    • in vitro fertilization (IVF)

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