Influence of 'feedback' signals on spatial integration in receptive fields of cat area 17 neurons

Chun Wang, Jin Huang, Cedric Bardy, Thomas Fitzgibbon, Bogdan Dreher

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    'Feedback' signals from mammalian extrastriate visual cortices are reported to exert primarily an excitatory influence on the classical receptive field (CRF) of neurons in the primary visual cortex (V1). However, given the much larger CRFs of neurons in extrastriate visual cortices it is not yet understood how feedback signals influence the spatial integration of visual signals by V1 neurons. To investigate this, we reversibly inactivated one of the 'form-processing' extrastriate visual cortices, the postero-temporal visual (PTV) cortex, and examined changes in responses of V1 neurons to drifting grating patches up to 28° in diameter. We found that during inactivation of PTV cortex the magnitude of the responses to CRF-confined stimuli and that to large stimuli inducing maximum suppression (i.e. minimum responses) was significantly reduced, while the spatial extent of the CRF remained largely unaffected. As a result, the relative strength of the surround suppression increased marginally. This effect was apparent in both simple and complex cells. It was also strong and consistent in cells located in supragranular and infragranular layers. For those cells exhibiting some relief from surround suppression or 'counter-suppression' when large stimuli patches were applied, the effect on counter-suppression was heterogeneous. Overall, the relative integrated responses to the 28° grating patches were also decreased when PTV cortex was inactivated. Thus, a substantial reduction in the CRF response and the largely unaffected spatial extent of the CRF as well as a weak surround effect observed in the present study are consistent with a multiplicative scaling effect.

    Original languageEnglish
    Pages (from-to)34-48
    Number of pages15
    JournalBrain Research
    Volume1328
    DOIs
    Publication statusPublished - 30 Apr 2010

    Keywords

    • Counter-suppression
    • CRF response
    • Electrophysiology
    • Postero-temporal visual cortex
    • Reversible cortical inactivation
    • Single unit recording
    • Surround suppression
    • Vision

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