Influence of metabolic syndrome on outcome after percutaneous coronary intervention

Vidyasagar Kalahasti; Derek Chew; Vijay Nambi; Stephen Minor; Ryan Zuzek; Stephen Ellis; Deepak Bhatt

doi:10.2217/ica.11.80

Influence of metabolic syndrome on outcome after percutaneous coronary intervention

Vidyasagar Kalahasti, Derek Chew, Vijay Nambi, Stephen Minor, Ryan Zuzek, Stephen Ellis, Deepak Bhatt

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Objective: To study the effect of metabolic syndrome (MetSyn) on cardiovascular outcomes after percutaneous coronary intervention (PCI) with bare-metal stents (BMS). Background: The constellation of dyslipidemia, impaired fasting glucose, high blood pressure and abdominal obesity is recognized as MetSyn. MetSyn increases mortality after coronary artery bypass grafting. The influence of MetSyn on outcomes after PCI is less well studied. Results: The influence of MetSyn on major adverse cardiac events (MACE) in PCI patients with BMS was studied. MetSyn factors showed a significant relationship to MACE. When compared with no MetSyn factors, the adjusted hazard ratio for one and four MetSyn factors was 1.24 (95% CI: 0.85-1.81) and 1.65 (1.11-2.45), respectively. Cox regression identified MetSyn as a significant predictor of MACE. Conclusion: MetSyn increases MACE risk in PCI patients with BMS. The risk is worse with increasing number of MetSyn components. Aggressive treatment of patients with MetSyn after PCI is warranted.

Original language	English
Pages (from-to)	721-726
Number of pages	6
Journal	Interventional Cardiology
Volume	3
Issue number	6
DOIs	https://doi.org/10.2217/ica.11.80
Publication status	Published - Dec 2011

Keywords

bare-metal stents
drug-eluting stents
major adverse cardiac events
metabolic syndrome
percutaneous coronary intervention

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{564ed5544af44f8e8b2785cc90c87054,

title = "Influence of metabolic syndrome on outcome after percutaneous coronary intervention",

abstract = "Objective: To study the effect of metabolic syndrome (MetSyn) on cardiovascular outcomes after percutaneous coronary intervention (PCI) with bare-metal stents (BMS). Background: The constellation of dyslipidemia, impaired fasting glucose, high blood pressure and abdominal obesity is recognized as MetSyn. MetSyn increases mortality after coronary artery bypass grafting. The influence of MetSyn on outcomes after PCI is less well studied. Results: The influence of MetSyn on major adverse cardiac events (MACE) in PCI patients with BMS was studied. MetSyn factors showed a significant relationship to MACE. When compared with no MetSyn factors, the adjusted hazard ratio for one and four MetSyn factors was 1.24 (95% CI: 0.85-1.81) and 1.65 (1.11-2.45), respectively. Cox regression identified MetSyn as a significant predictor of MACE. Conclusion: MetSyn increases MACE risk in PCI patients with BMS. The risk is worse with increasing number of MetSyn components. Aggressive treatment of patients with MetSyn after PCI is warranted.",

keywords = "bare-metal stents, drug-eluting stents, major adverse cardiac events, metabolic syndrome, percutaneous coronary intervention",

author = "Vidyasagar Kalahasti and Derek Chew and Vijay Nambi and Stephen Minor and Ryan Zuzek and Stephen Ellis and Deepak Bhatt",

year = "2011",

month = dec,

doi = "10.2217/ica.11.80",

language = "English",

volume = "3",

pages = "721--726",

journal = "Interventional Cardiology",

issn = "1755-5302",

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}

TY - JOUR

T1 - Influence of metabolic syndrome on outcome after percutaneous coronary intervention

AU - Kalahasti, Vidyasagar

AU - Chew, Derek

AU - Nambi, Vijay

AU - Minor, Stephen

AU - Zuzek, Ryan

AU - Ellis, Stephen

AU - Bhatt, Deepak

PY - 2011/12

Y1 - 2011/12

N2 - Objective: To study the effect of metabolic syndrome (MetSyn) on cardiovascular outcomes after percutaneous coronary intervention (PCI) with bare-metal stents (BMS). Background: The constellation of dyslipidemia, impaired fasting glucose, high blood pressure and abdominal obesity is recognized as MetSyn. MetSyn increases mortality after coronary artery bypass grafting. The influence of MetSyn on outcomes after PCI is less well studied. Results: The influence of MetSyn on major adverse cardiac events (MACE) in PCI patients with BMS was studied. MetSyn factors showed a significant relationship to MACE. When compared with no MetSyn factors, the adjusted hazard ratio for one and four MetSyn factors was 1.24 (95% CI: 0.85-1.81) and 1.65 (1.11-2.45), respectively. Cox regression identified MetSyn as a significant predictor of MACE. Conclusion: MetSyn increases MACE risk in PCI patients with BMS. The risk is worse with increasing number of MetSyn components. Aggressive treatment of patients with MetSyn after PCI is warranted.

AB - Objective: To study the effect of metabolic syndrome (MetSyn) on cardiovascular outcomes after percutaneous coronary intervention (PCI) with bare-metal stents (BMS). Background: The constellation of dyslipidemia, impaired fasting glucose, high blood pressure and abdominal obesity is recognized as MetSyn. MetSyn increases mortality after coronary artery bypass grafting. The influence of MetSyn on outcomes after PCI is less well studied. Results: The influence of MetSyn on major adverse cardiac events (MACE) in PCI patients with BMS was studied. MetSyn factors showed a significant relationship to MACE. When compared with no MetSyn factors, the adjusted hazard ratio for one and four MetSyn factors was 1.24 (95% CI: 0.85-1.81) and 1.65 (1.11-2.45), respectively. Cox regression identified MetSyn as a significant predictor of MACE. Conclusion: MetSyn increases MACE risk in PCI patients with BMS. The risk is worse with increasing number of MetSyn components. Aggressive treatment of patients with MetSyn after PCI is warranted.

KW - bare-metal stents

KW - drug-eluting stents

KW - major adverse cardiac events

KW - metabolic syndrome

KW - percutaneous coronary intervention

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U2 - 10.2217/ica.11.80

DO - 10.2217/ica.11.80

M3 - Article

SN - 1755-5302

VL - 3

SP - 721

EP - 726

JO - Interventional Cardiology

JF - Interventional Cardiology

IS - 6

ER -

Influence of metabolic syndrome on outcome after percutaneous coronary intervention

Abstract

Keywords

UN SDGs

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