Influence of sex and oral contraceptive steroids on paracetamol metabolism.

JO Miners, J. Attwood, DJ Birkett

    Research output: Contribution to journalArticlepeer-review

    163 Citations (Scopus)

    Abstract

    Paracetamol metabolism was investigated in eight healthy males, eight healthy females and eight healthy females receiving oral contraceptive steroids (OCS). Paracetamol clearance was 22% greater in males compared to the control female group. This difference was entirely due to increased activity of the glucuronidation pathway in males, there being no sex‐related differences in the sulphation or oxidative metabolism of paracetamol. Paracetamol clearance in females using OCS was 49% greater than in the control females. Glucuronidation and oxidative metabolism were both induced in OCS users (by 78% and 36% respectively) but sulphation was not altered. Although sex‐related differences in paracetamol metabolism are unlikely to be of clinical importance, induction of paracetamol metabolism by OCS may have clinical and toxicological consequences. 1983 The British Pharmacological Society

    Original languageEnglish
    Pages (from-to)503-509
    Number of pages7
    JournalBritish Journal of Clinical Pharmacology
    Volume16
    Issue number5
    DOIs
    Publication statusPublished - Nov 1983

    Fingerprint

    Dive into the research topics of 'Influence of sex and oral contraceptive steroids on paracetamol metabolism.'. Together they form a unique fingerprint.

    Cite this