Information technologies for vaccine research

Vladimir Brusic, J. Thomas August, Nikolai Petrovsky

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

Vaccinology is a combinatorial science which studies the diversity of pathogens and the human immune system, and formulations that can modulate immune responses and prevent or cure disease. Huge amounts of data are produced by genomics and proteomics projects and large-scale screening of pathogen-host and antigen-host interactions. Current developments in computational vaccinology mainly support the analysis of antigen processing and presentation and the characterization of targets of immune response. Future development will also include systemic models of vaccine responses. Immunomics, the large-scale screening of immune processes which includes powerful immunoinformatic tools, offers great promise for future translation of basic immunology research advances into successful vaccines.

Original languageEnglish
Pages (from-to)407-417
Number of pages11
JournalExpert Review of Vaccines
Volume4
Issue number3
DOIs
Publication statusPublished - 1 Jun 2005
Externally publishedYes

Keywords

  • Computational vaccinology
  • Immunoinformatics
  • Immunologic databases
  • Immunomics
  • T-cell epitope prediction

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