Initiation of DNA synthesis in rat thymus: Correlation of calcium-dependent initiation in thymocytes and in isolated thymus nuclei

Leigh A. Burgoyne; M. Anwar Waqar; Maurice R. Atkinson

doi:10.1016/0006-291X(70)90411-0

Initiation of DNA synthesis in rat thymus: Correlation of calcium-dependent initiation in thymocytes and in isolated thymus nuclei

Leigh A. Burgoyne
, M. Anwar Waqar
, Maurice R. Atkinson

College of Science and Engineering

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Initiation of DNA synthesis in nuclei isolated from rat thymus is stimulated by Ca²⁺, as shown in previous studies with liver nuclei. 3′,5′-Cyclic AMP did not replace Ca²⁺ in either system. The relationship of this Ca²⁺-dependent stimulation to published reports of Ca²⁺-dependent promotion of mitosis in vivo and to Ca²⁺ stimulation of initiation of DNA synthesis in isolated thymocytes, is discussed.

Original language	English
Pages (from-to)	918-922
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	39
Issue number	5
DOIs	https://doi.org/10.1016/0006-291X(70)90411-0
Publication status	Published - 5 Jun 1970

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title = "Initiation of DNA synthesis in rat thymus: Correlation of calcium-dependent initiation in thymocytes and in isolated thymus nuclei",

abstract = "Initiation of DNA synthesis in nuclei isolated from rat thymus is stimulated by Ca2+, as shown in previous studies with liver nuclei. 3′,5′-Cyclic AMP did not replace Ca2+ in either system. The relationship of this Ca2+-dependent stimulation to published reports of Ca2+-dependent promotion of mitosis in vivo and to Ca2+ stimulation of initiation of DNA synthesis in isolated thymocytes, is discussed.",

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T2 - Correlation of calcium-dependent initiation in thymocytes and in isolated thymus nuclei

AU - Burgoyne, Leigh A.

AU - Waqar, M. Anwar

AU - Atkinson, Maurice R.

PY - 1970/6/5

Y1 - 1970/6/5

N2 - Initiation of DNA synthesis in nuclei isolated from rat thymus is stimulated by Ca2+, as shown in previous studies with liver nuclei. 3′,5′-Cyclic AMP did not replace Ca2+ in either system. The relationship of this Ca2+-dependent stimulation to published reports of Ca2+-dependent promotion of mitosis in vivo and to Ca2+ stimulation of initiation of DNA synthesis in isolated thymocytes, is discussed.

AB - Initiation of DNA synthesis in nuclei isolated from rat thymus is stimulated by Ca2+, as shown in previous studies with liver nuclei. 3′,5′-Cyclic AMP did not replace Ca2+ in either system. The relationship of this Ca2+-dependent stimulation to published reports of Ca2+-dependent promotion of mitosis in vivo and to Ca2+ stimulation of initiation of DNA synthesis in isolated thymocytes, is discussed.

UR - https://www.scopus.com/pages/publications/0014933372

U2 - 10.1016/0006-291X(70)90411-0

DO - 10.1016/0006-291X(70)90411-0

M3 - Article

C2 - 4316431

AN - SCOPUS:0014933372

SN - 0006-291X

VL - 39

SP - 918

EP - 922

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 5

ER -

Initiation of DNA synthesis in rat thymus: Correlation of calcium-dependent initiation in thymocytes and in isolated thymus nuclei

Abstract

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