TY - JOUR
T1 - Initiation of DNA synthesis in rat thymus
T2 - Correlation of calcium-dependent initiation in thymocytes and in isolated thymus nuclei
AU - Burgoyne, Leigh A.
AU - Waqar, M. Anwar
AU - Atkinson, Maurice R.
PY - 1970/6/5
Y1 - 1970/6/5
N2 - Initiation of DNA synthesis in nuclei isolated from rat thymus is stimulated by Ca2+, as shown in previous studies with liver nuclei. 3′,5′-Cyclic AMP did not replace Ca2+ in either system. The relationship of this Ca2+-dependent stimulation to published reports of Ca2+-dependent promotion of mitosis in vivo and to Ca2+ stimulation of initiation of DNA synthesis in isolated thymocytes, is discussed.
AB - Initiation of DNA synthesis in nuclei isolated from rat thymus is stimulated by Ca2+, as shown in previous studies with liver nuclei. 3′,5′-Cyclic AMP did not replace Ca2+ in either system. The relationship of this Ca2+-dependent stimulation to published reports of Ca2+-dependent promotion of mitosis in vivo and to Ca2+ stimulation of initiation of DNA synthesis in isolated thymocytes, is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0014933372&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(70)90411-0
DO - 10.1016/0006-291X(70)90411-0
M3 - Article
C2 - 4316431
AN - SCOPUS:0014933372
SN - 0006-291X
VL - 39
SP - 918
EP - 922
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 5
ER -