Innate Immunity

Eng Ooi; Alkis Psaltis; Ian Witterick; Peter Wormald

doi:10.1016/j.otc.2010.02.020

Innate Immunity

Eng Ooi, Alkis Psaltis, Ian Witterick, Peter Wormald

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic rhinosinusitis (CRS). This article reviews important recent research regarding the innate immune system and CRS, with particular focus on the role of pattern recognition receptors, antimicrobial peptides and biofilms, epithelial ciliary function, cystic fibrosis, and cigarette smoking, and on areas for future research and therapy.

Original language	English
Pages (from-to)	473-487
Number of pages	15
Journal	Otolaryngologic Clinics of North America
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.otc.2010.02.020
Publication status	Published - Jun 2010

Keywords

Biofilms
Cigarette smoke
Cystic fibrosis
Innate immunity
Rhinosinusitis
Toll-like receptors

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AU - Psaltis, Alkis

AU - Witterick, Ian

AU - Wormald, Peter

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AB - Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic rhinosinusitis (CRS). This article reviews important recent research regarding the innate immune system and CRS, with particular focus on the role of pattern recognition receptors, antimicrobial peptides and biofilms, epithelial ciliary function, cystic fibrosis, and cigarette smoking, and on areas for future research and therapy.

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KW - Cigarette smoke

KW - Cystic fibrosis

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KW - Rhinosinusitis

KW - Toll-like receptors

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JF - Otolaryngologic Clinics of North America

SN - 0030-6665

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ER -

Innate Immunity

Abstract

Keywords

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