Innate Immunity

Eng Ooi, Alkis Psaltis, Ian Witterick, Peter Wormald

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)


    Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic rhinosinusitis (CRS). This article reviews important recent research regarding the innate immune system and CRS, with particular focus on the role of pattern recognition receptors, antimicrobial peptides and biofilms, epithelial ciliary function, cystic fibrosis, and cigarette smoking, and on areas for future research and therapy.

    Original languageEnglish
    Pages (from-to)473-487
    Number of pages15
    JournalOtolaryngologic Clinics of North America
    Issue number3
    Publication statusPublished - Jun 2010


    • Biofilms
    • Cigarette smoke
    • Cystic fibrosis
    • Innate immunity
    • Rhinosinusitis
    • Toll-like receptors


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