Abstract
Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic rhinosinusitis (CRS). This article reviews important recent research regarding the innate immune system and CRS, with particular focus on the role of pattern recognition receptors, antimicrobial peptides and biofilms, epithelial ciliary function, cystic fibrosis, and cigarette smoking, and on areas for future research and therapy.
Original language | English |
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Pages (from-to) | 473-487 |
Number of pages | 15 |
Journal | Otolaryngologic Clinics of North America |
Volume | 43 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jun 2010 |
Keywords
- Biofilms
- Cigarette smoke
- Cystic fibrosis
- Innate immunity
- Rhinosinusitis
- Toll-like receptors