Innate Immunity

Eng H. Ooi; Alkis J. Psaltis; Ian J. Witterick; Peter-John Wormald

doi:10.1016/j.otc.2010.02.020

Innate Immunity

Eng H. Ooi, Alkis J. Psaltis, Ian J. Witterick, Peter-John Wormald

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic rhinosinusitis (CRS). This article reviews important recent research regarding the innate immune system and CRS, with particular focus on the role of pattern recognition receptors, antimicrobial peptides and biofilms, epithelial ciliary function, cystic fibrosis, and cigarette smoking, and on areas for future research and therapy.

Original language	English
Pages (from-to)	473-487
Number of pages	15
Journal	Otolaryngologic Clinics of North America
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.otc.2010.02.020
Publication status	Published - Jun 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biofilms
Cigarette smoke
Cystic fibrosis
Innate immunity
Rhinosinusitis
Toll-like receptors

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10.1016/j.otc.2010.02.020Licence: In Copyright

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title = "Innate Immunity",

abstract = "Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic rhinosinusitis (CRS). This article reviews important recent research regarding the innate immune system and CRS, with particular focus on the role of pattern recognition receptors, antimicrobial peptides and biofilms, epithelial ciliary function, cystic fibrosis, and cigarette smoking, and on areas for future research and therapy.",

keywords = "Biofilms, Cigarette smoke, Cystic fibrosis, Innate immunity, Rhinosinusitis, Toll-like receptors",

author = "Ooi, {Eng H.} and Psaltis, {Alkis J.} and Witterick, {Ian J.} and Peter-John Wormald",

year = "2010",

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language = "English",

volume = "43",

pages = "473--487",

journal = "Otolaryngologic Clinics of North America",

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T1 - Innate Immunity

AU - Ooi, Eng H.

AU - Psaltis, Alkis J.

AU - Witterick, Ian J.

AU - Wormald, Peter-John

PY - 2010/6

Y1 - 2010/6

N2 - Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic rhinosinusitis (CRS). This article reviews important recent research regarding the innate immune system and CRS, with particular focus on the role of pattern recognition receptors, antimicrobial peptides and biofilms, epithelial ciliary function, cystic fibrosis, and cigarette smoking, and on areas for future research and therapy.

AB - Innate immunity is an exciting area of research in rhinology because emerging evidence suggests that abnormal local immune responses, rather than pathogen-specific adaptive immunity, may play a more important role in the pathogenesis of chronic rhinosinusitis (CRS). This article reviews important recent research regarding the innate immune system and CRS, with particular focus on the role of pattern recognition receptors, antimicrobial peptides and biofilms, epithelial ciliary function, cystic fibrosis, and cigarette smoking, and on areas for future research and therapy.

KW - Biofilms

KW - Cigarette smoke

KW - Cystic fibrosis

KW - Innate immunity

KW - Rhinosinusitis

KW - Toll-like receptors

UR - http://www.scopus.com/inward/record.url?scp=77953489262&partnerID=8YFLogxK

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DO - 10.1016/j.otc.2010.02.020

M3 - Article

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VL - 43

SP - 473

EP - 487

JO - Otolaryngologic Clinics of North America

JF - Otolaryngologic Clinics of North America

IS - 3

ER -

Innate Immunity

Abstract

UN SDGs

Keywords

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