Inspiration from Old Dyes: Tris(stilbene) Compounds as Potent Gram-Positive Antibacterial Agents

Ramiz Boulos, Nikki Man, Nigel Lengkeek, Katherine Hammer, Niki Foster, Natalie Stemberger, Brian Skelton, Pan Wong, Boris Martinac, Thomas Riley, Allan McKinley, Scott Stewart

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Herein we describe the preparation and structure-activity relationship studies on range of stilbene based compounds and their antibacterial activity. Two related compounds, each bearing carboxylic acid moieties, exhibit good activity against several bacterial strains, including methicillin-resistant Staphylococcus aureus MRSA (ATCC 33592 and NCTC 10442). Compound 10 was most active against Moraxella catarrhalis with minimum inhibitory concentrations (MICs) of 0.12-0.25 μg mL-1 and against Staphylococcus spp. with MICs ranging from 2-4 μg mL-1. The derivative 17 showed increased activity with MICs of 0.06-0.25 μg mL-1 against M. catarrhalis and 0.12-1 against Staphylococcus spp. This level of activity is similar to that reported for S. aureus for antibiotics, such as vancomycin, with MICs of ≤2.0 μg mL-1 and clindamycin with MICs of ≤0.5 μg mL -1. As an indicator of toxicity, 17 was tested for its ability to lyse sheep erythrocytes, and showed low haemolytic activity. Such results highlight the value of tris(stilbene) compounds as antibacterial agents providing suitable properties for further development. Routes to new antibiotics: The preparation of and structure-activity relationship studies on a range of stilbene based compounds revealed two related compounds, each bearing carboxylic acid moieties, exhibiting pronounced activity against several bacterial strains including methicillin-resistant Staphylococcus aureus, MRSA (see scheme, dba = dibenzylidene acetone).

    Original languageEnglish
    Pages (from-to)17980-17988
    Number of pages9
    JournalChemistry-A European Journal
    Volume19
    Issue number52
    DOIs
    Publication statusPublished - 2013

    Fingerprint Dive into the research topics of 'Inspiration from Old Dyes: Tris(stilbene) Compounds as Potent Gram-Positive Antibacterial Agents'. Together they form a unique fingerprint.

  • Cite this

    Boulos, R., Man, N., Lengkeek, N., Hammer, K., Foster, N., Stemberger, N., Skelton, B., Wong, P., Martinac, B., Riley, T., McKinley, A., & Stewart, S. (2013). Inspiration from Old Dyes: Tris(stilbene) Compounds as Potent Gram-Positive Antibacterial Agents. Chemistry-A European Journal, 19(52), 17980-17988. https://doi.org/10.1002/chem.201303119