TY - JOUR
T1 - Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion
AU - Ziegler, Amber
AU - Chidambaram, Shravanthi
AU - Forbes, Briony
AU - Wood, Teresa
AU - Levison, Steven
PY - 2014/2/21
Y1 - 2014/2/21
N2 - Background: IGF-II promotes neural stem cell (NSC) proliferation and self-renewal. Results: IGF-II analogs are useful for elucidating the receptors responsible for NSC expansion. Conclusion: F19A expands NSCs via IR-A. Significance: IGF-II promotes stemness of NSCs via the IR-A and not through activation of either the IGF-1R or the IGF-2R.
AB - Background: IGF-II promotes neural stem cell (NSC) proliferation and self-renewal. Results: IGF-II analogs are useful for elucidating the receptors responsible for NSC expansion. Conclusion: F19A expands NSCs via IR-A. Significance: IGF-II promotes stemness of NSCs via the IR-A and not through activation of either the IGF-1R or the IGF-2R.
UR - http://www.jbc.org/content/289/8/4626.long
UR - http://www.scopus.com/inward/record.url?scp=84896698439&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.537597
DO - 10.1074/jbc.M113.537597
M3 - Article
SN - 0021-9258
VL - 289
SP - 4626
EP - 4633
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 8
ER -