Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion

Amber Ziegler, Shravanthi Chidambaram, Briony Forbes, Teresa Wood, Steven Levison

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    Background: IGF-II promotes neural stem cell (NSC) proliferation and self-renewal. Results: IGF-II analogs are useful for elucidating the receptors responsible for NSC expansion. Conclusion: F19A expands NSCs via IR-A. Significance: IGF-II promotes stemness of NSCs via the IR-A and not through activation of either the IGF-1R or the IGF-2R.

    Original languageEnglish
    Pages (from-to)4626-4633
    Number of pages8
    JournalJournal of Biological Chemistry
    Volume289
    Issue number8
    DOIs
    Publication statusPublished - 21 Feb 2014

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