Integrating thin film microfluidics in developing a concise synthesis of DGJNAc: a potent inhibitor of α-N-acetylgalctosaminidases

Siobhán S. Wills; Colin L. Raston; Keith A. Stubbs

doi:10.1016/j.bmcl.2018.10.015

Integrating thin film microfluidics in developing a concise synthesis of DGJNAc: a potent inhibitor of α-N-acetylgalctosaminidases

Siobhán S. Wills, Colin L. Raston, Keith A. Stubbs

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A simple synthesis, which utilizes a thin film microfluidic reactor for a problematic step, of a potent inhibitor of α-N-acetylhexosaminidases, DGJNAc, has been developed.

Original language	English
Pages (from-to)	3748-3751
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	28
Issue number	23-24
DOIs	https://doi.org/10.1016/j.bmcl.2018.10.015
Publication status	Published - 15 Dec 2018
Externally published	Yes

Keywords

Flow chemistry
Glycosidases
Iminosugars
Inhibitors
Thin film microfluidics

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10.1016/j.bmcl.2018.10.015Licence: In Copyright

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abstract = "A simple synthesis, which utilizes a thin film microfluidic reactor for a problematic step, of a potent inhibitor of α-N-acetylhexosaminidases, DGJNAc, has been developed.",

keywords = "Flow chemistry, Glycosidases, Iminosugars, Inhibitors, Thin film microfluidics",

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AU - Raston, Colin L.

AU - Stubbs, Keith A.

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KW - Iminosugars

KW - Inhibitors

KW - Thin film microfluidics

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ER -

Integrating thin film microfluidics in developing a concise synthesis of DGJNAc: a potent inhibitor of α-N-acetylgalctosaminidases

Abstract

Keywords

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