Abstract
To assess the effects of intensive glucose control on the risk of major clinical outcomes according to estimated glomerular filtration rate (eGFR) levels in people with type 2 diabetes. Of 11 140 ADVANCE trial participants, 11 096 with baseline eGFR measurements were included, and classified into three eGFR groups: ≥90 mL/min/1.73 m2; 60 to 89 mL/min/1.73 m2; and < 60 mL/min/1.73 m2. Relative risk reduction of randomized intensive glucose control with regard to the composite outcome of major macro- and microvascular events, all-cause death and cardiovascular death did not significantly vary by eGFR level (P for heterogeneity ≥0.49). The risk of severe hypoglycaemia increased with intensive glucose control; however, this risk did not vary across eGFR groups (P for heterogeneity = 0.83). The risk–benefit profile of intensive glucose control in patients with type 2 diabetes and impaired kidney function appears similar to that observed in those with preserved kidney function.
Original language | English |
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Pages (from-to) | 452-457 |
Number of pages | 6 |
Journal | Diabetes, Obesity and Metabolism |
Volume | 22 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2020 |
Externally published | Yes |
Keywords
- cardiovascular disease
- clinical trial
- glycaemic control
- hypoglycaemia
- type 2 diabetes