Interaction of Campylobacter pyloridis with human immune defence mechanisms

H. Pruul; P. C. Lee; C. S. Goodwin; P. J. McDonald

doi:10.1099/00222615-23-3-233

Interaction of Campylobacter pyloridis with human immune defence mechanisms

H. Pruul, P. C. Lee, C. S. Goodwin, P. J. McDonald

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20 Citations (Scopus)

Abstract

The in-vitro susceptibility to host immune defence mechanisms of Campylobacter pyloridis was investigated. C. pyloridis was sensitive to antibody-dependent complement-mediated bactericidal activity of serum. The bacteria were phagocytosed and efficiently killed by polymorphonuclear neutrophils in the presence of serum opsonins. Serum opsonin depletion studies indicated that an intact classical complement pathway was required for optimal phagocytic killing.

Original language	English
Pages (from-to)	233-238
Number of pages	6
Journal	Journal of Medical Microbiology
Volume	23
Issue number	3
DOIs	https://doi.org/10.1099/00222615-23-3-233
Publication status	Published - 1 May 1987
Externally published	Yes

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author = "H. Pruul and Lee, {P. C.} and Goodwin, {C. S.} and McDonald, {P. J.}",

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N2 - The in-vitro susceptibility to host immune defence mechanisms of Campylobacter pyloridis was investigated. C. pyloridis was sensitive to antibody-dependent complement-mediated bactericidal activity of serum. The bacteria were phagocytosed and efficiently killed by polymorphonuclear neutrophils in the presence of serum opsonins. Serum opsonin depletion studies indicated that an intact classical complement pathway was required for optimal phagocytic killing.

AB - The in-vitro susceptibility to host immune defence mechanisms of Campylobacter pyloridis was investigated. C. pyloridis was sensitive to antibody-dependent complement-mediated bactericidal activity of serum. The bacteria were phagocytosed and efficiently killed by polymorphonuclear neutrophils in the presence of serum opsonins. Serum opsonin depletion studies indicated that an intact classical complement pathway was required for optimal phagocytic killing.

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Interaction of Campylobacter pyloridis with human immune defence mechanisms

Abstract

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