Interaction of Silver Nanoparticles with Tethered Bilayer Lipid Membranes

Renee Goreham, Vanessa Thompson, Yuya Samura, Christopher Gibson, Joseph Shapter, Ingo Koper

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    Silver nanoparticles are well-known for their antibacterial properties. However, the detailed mechanism describing the interaction between the nanoparticles and a cell membrane is not fully understood, which can impede the use of the particles in biomedical applications. Here, a tethered bilayer lipid membrane has been used as a model system to mimic a natural membrane and to study the effect of exposure to small silver nanoparticles with diameters of about 2 nm. The solid supported membrane architecture allowed for the application of surface analytical techniques such as electrochemical impedance spectroscopy and atomic force microscopy. Exposure of the membrane to solutions of the silver nanoparticles led to a small but completely reversible perturbation of the lipid bilayer.

    Original languageEnglish
    Pages (from-to)5868-5874
    Number of pages7
    JournalLangmuir
    Volume31
    Issue number21
    DOIs
    Publication statusPublished - 2 Jun 2015

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