Interethnic differences in drug glucuronidation: a comparison of paracetamol metabolism in Caucasians and Chinese.

NJ Osborne, AL Tonkin, JO Miners

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Paracetamol disposition following a single oral 1 g dose of the drug was compared in groups (n = 12) of healthy young adult male Caucasians and Chinese. There was no difference between the groups in terms of paracetamol oral clearance, elimination half‐life, or partial metabolic (glucuronidation, sulphation, oxidation) and renal clearances. The results demonstrate that drug glucuronidation is not universally impaired in Chinese and, together with previously published data, that paracetamol glucuronidation is minimally affected by race. 1991 The British Pharmacological Society

Original languageEnglish
Pages (from-to)765-767
Number of pages3
JournalBritish Journal of Clinical Pharmacology
Volume32
Issue number6
DOIs
Publication statusPublished - Dec 1991
Externally publishedYes

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