TY - JOUR
T1 - Interethnic differences in drug glucuronidation
T2 - a comparison of paracetamol metabolism in Caucasians and Chinese.
AU - Osborne, NJ
AU - Tonkin, AL
AU - Miners, JO
PY - 1991/12
Y1 - 1991/12
N2 - Paracetamol disposition following a single oral 1 g dose of the drug was compared in groups (n = 12) of healthy young adult male Caucasians and Chinese. There was no difference between the groups in terms of paracetamol oral clearance, elimination half‐life, or partial metabolic (glucuronidation, sulphation, oxidation) and renal clearances. The results demonstrate that drug glucuronidation is not universally impaired in Chinese and, together with previously published data, that paracetamol glucuronidation is minimally affected by race. 1991 The British Pharmacological Society
AB - Paracetamol disposition following a single oral 1 g dose of the drug was compared in groups (n = 12) of healthy young adult male Caucasians and Chinese. There was no difference between the groups in terms of paracetamol oral clearance, elimination half‐life, or partial metabolic (glucuronidation, sulphation, oxidation) and renal clearances. The results demonstrate that drug glucuronidation is not universally impaired in Chinese and, together with previously published data, that paracetamol glucuronidation is minimally affected by race. 1991 The British Pharmacological Society
UR - http://www.scopus.com/inward/record.url?scp=0025840257&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2125.1991.tb03988.x
DO - 10.1111/j.1365-2125.1991.tb03988.x
M3 - Article
C2 - 1768572
AN - SCOPUS:0025840257
VL - 32
SP - 765
EP - 767
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
SN - 0306-5251
IS - 6
ER -