Interleukin 2 receptor antagonists for kidney transplant recipients

Angela C. Webster; Elliott Geoffrey Playford; Gail Y. Higgins; Jeremy R Chapman; Jonathan C. Craig

doi:10.1002/14651858.CD003897.pub2

Interleukin 2 receptor antagonists for kidney transplant recipients

Angela C. Webster, Elliott Geoffrey Playford, Gail Y. Higgins, Jeremy R Chapman, Jonathan C. Craig

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

Abstract

Acute rejection is a major problem in the early period following kidney transplantation. Immunosuppressive drugs are used to prevent this. IL2Ra, a new class antibody therapy, can be added to a patient's existing immunosuppression to further reduce the risk of rejection. This review found that IL2Ra reduced the risk of acute rejection at six and 12 months after kidney transplantation but did not improve kidney or patient survival. IL2Ra treatment had fewer side effects than other antibody therapy.

Original language	English
Article number	CD003897
Journal	Cochrane Database of Systematic Reviews
Volume	2004
Issue number	1
DOIs	https://doi.org/10.1002/14651858.CD003897.pub2
Publication status	Published - 26 Jan 2004
Externally published	Yes

Keywords

kidney transplantation
recipients
Rejection

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title = "Interleukin 2 receptor antagonists for kidney transplant recipients",

abstract = "Acute rejection is a major problem in the early period following kidney transplantation. Immunosuppressive drugs are used to prevent this. IL2Ra, a new class antibody therapy, can be added to a patient's existing immunosuppression to further reduce the risk of rejection. This review found that IL2Ra reduced the risk of acute rejection at six and 12 months after kidney transplantation but did not improve kidney or patient survival. IL2Ra treatment had fewer side effects than other antibody therapy. ",

keywords = "kidney transplantation, recipients, Rejection",

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AU - Webster, Angela C.

AU - Playford, Elliott Geoffrey

AU - Higgins, Gail Y.

AU - Chapman, Jeremy R

AU - Craig, Jonathan C.

PY - 2004/1/26

Y1 - 2004/1/26

N2 - Acute rejection is a major problem in the early period following kidney transplantation. Immunosuppressive drugs are used to prevent this. IL2Ra, a new class antibody therapy, can be added to a patient's existing immunosuppression to further reduce the risk of rejection. This review found that IL2Ra reduced the risk of acute rejection at six and 12 months after kidney transplantation but did not improve kidney or patient survival. IL2Ra treatment had fewer side effects than other antibody therapy.

AB - Acute rejection is a major problem in the early period following kidney transplantation. Immunosuppressive drugs are used to prevent this. IL2Ra, a new class antibody therapy, can be added to a patient's existing immunosuppression to further reduce the risk of rejection. This review found that IL2Ra reduced the risk of acute rejection at six and 12 months after kidney transplantation but did not improve kidney or patient survival. IL2Ra treatment had fewer side effects than other antibody therapy.

KW - kidney transplantation

KW - recipients

KW - Rejection

U2 - 10.1002/14651858.CD003897.pub2

DO - 10.1002/14651858.CD003897.pub2

M3 - Article

SN - 1469-493X

VL - 2004

JO - Cochrane Database of Systematic Reviews

JF - Cochrane Database of Systematic Reviews

IS - 1

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ER -

Interleukin 2 receptor antagonists for kidney transplant recipients

Abstract

Keywords

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