International consensus definition of low anterior resection syndrome

Celia Keane, Nicola S. Fearnhead, Liliana G. Bordeianou, Peter Christensen, Eloy Espin Basany, Søren Laurberg, Anders Mellgren, Craig Messick, Guy R. Orangio, Azmina Verjee, Kirsty Wing, Ian Bissett, LARS International Collaborative Group, P. Dinning

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Abstract

BACKGROUND: Low anterior resection syndrome is pragmatically defined as disordered bowel function after rectal resection leading to a detriment in quality of life. This broad characterization does not allow for precise estimates of prevalence. The low anterior resection syndrome score was designed as a simple tool for clinical evaluation of low anterior resection syndrome. Although the low anterior resection syndrome score has good clinical utility, it may not capture all important aspects that patients may experience. OBJECTIVE: The aim of this collaboration was to develop an international consensus definition of low anterior resection syndrome that encompasses all aspects of the condition and is informed by all stakeholders. DESIGN: This international patient-provider initiative used an online Delphi survey, regional patient consultation meetings, and an international consensus meeting. PARTICIPANTS: Three expert groups participated: patients, surgeons, and other health professionals from 5 regions (Australasia, Denmark, Spain, Great Britain and Ireland, and North America) and in 3 languages (English, Spanish, and Danish). MAIN OUTCOME MEASURE: The primary outcome measured was the priorities for the definition of low anterior resection syndrome. RESULTS: Three hundred twenty-five participants (156 patients) registered. The response rates for successive rounds of the Delphi survey were 86%, 96%, and 99%. Eighteen priorities emerged from the Delphi survey. Patient consultation and consensus meetings refined these priorities to 8 symptoms and 8 consequences that capture essential aspects of the syndrome. LIMITATIONS: Sampling bias may have been present, in particular, in the patient panel because social media was used extensively in recruitment. There was also dominance of the surgical panel at the final consensus meeting despite attempts to mitigate this. CONCLUSIONS: This is the first definition of low anterior resection syndrome developed with direct input from a large international patient panel. The involvement of patients in all phases has ensured that the definition presented encompasses the vital aspects of the patient experience of low anterior resection syndrome. The novel separation of symptoms and consequences may enable greater sensitivity to detect changes in low anterior resection syndrome over time and with intervention.

Original languageEnglish
Pages (from-to)274-284
Number of pages11
JournalDiseases of The Colon and Rectum
Volume63
Issue number3
DOIs
Publication statusPublished - Mar 2020

Bibliographical note

This article is being published concurrently in Diseases of the Colon & Rectum, Colorectal Disease and ANZ Journal of Surgery. The articles are identical exceptfor minor stylistic and spelling differences in keeping with each journal’s style. Citation from any of the three journals can be used when citing this article.

Keywords

  • Consensus definition
  • Low anterior resection syndrome
  • Patient reported
  • Rectal resection

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  • International consensus definition of low anterior resection syndrome

    Keane, C., Fearnhead, N. S., Bordeianou, L. G., Christensen, P., Basany, E. E., Laurberg, S., Mellgren, A., Messick, C., Orangio, G. R., Verjee, A., Wing, K., Bissett, I., LARS International Collaborative Group, Chen, T., Clark, D., Dinning, P., Brown, S., Edwards, C., Walsh, C., Abbott, S. & 3 others, Bennett, M., Vuong, T. & Wright, J., 1 Mar 2020, In : Colorectal Disease. 22, 3, p. 331-341 11 p.

    Research output: Contribution to journalArticle

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4 Citations (Scopus)
  • International consensus definition of low anterior resection syndrome

    Keane, C., Fearnhead, N. S., Bordeianou, L. G., Christensen, P., Basany, E. E., Laurberg, S., Mellgren, A., Messick, C., Orangio, G. R., Verjee, A., Wing, K., Bissett, I., LARS International Collaborative Group, Dinning, P. & Abbott, S., 1 Mar 2020, In : ANZ Journal of Surgery. 90, 3, p. 300-307 8 p.

    Research output: Contribution to journalArticle

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