TY - JOUR
T1 - International consensus definition of low anterior resection syndrome
AU - Keane, Celia
AU - Fearnhead, Nicola S.
AU - Bordeianou, Liliana G.
AU - Christensen, Peter
AU - Basany, Eloy Espin
AU - Laurberg, Søren
AU - Mellgren, Anders
AU - Messick, Craig
AU - Orangio, Guy R.
AU - Verjee, Azmina
AU - Wing, Kirsty
AU - Bissett, Ian
AU - LARS International Collaborative Group
AU - An, V.
AU - Bryant, A.
AU - Byrne, C.
AU - Chen, T.
AU - Croft, S.
AU - Clark, D.
AU - Gladman, M.
AU - Heriot, A.
AU - Kariappa, S.
AU - Keck, J.
AU - Lubowski, D.
AU - Dinning, P.
AU - Khera, A.
AU - Kirkwood, K.
AU - Petersen, D.
AU - Sloots, K.
AU - Totten, B.
AU - Weston, M.
AU - Andersen, P.
AU - Bachmann, C.
AU - Barht, H.
AU - Emmertsen, K.
AU - Faaborg, P.
AU - Gögenur, I.
AU - Ingerslev, P.
AU - Isaksen, D.
AU - Iversen, H.
AU - Iversen, L.
AU - Jacobsen, K.
AU - Jansen, T.
AU - Jocobsen, I.
AU - Juul, T.
AU - Kjar, D.
AU - Krogh, K.
AU - Majgaard, M.
AU - Mynster, A.
AU - Neuenschwander, A.
AU - Nielsen, C.
AU - Nielsen, R.
AU - Nielsen, M.
AU - Nielsen, T.
AU - Olsen, J.
AU - Poulsen, B.
AU - Rahr, H.
AU - Snedker, B.
AU - Sørensen, G.
AU - Stolzenburg, T.
AU - Vaabengaard, P.
AU - Acheson, A.
AU - Andreyev, J.
AU - Bach, S.
AU - Battersby, N.
AU - Bradbury, J.
AU - Brown, S.
AU - Cecil, T.
AU - Chapman, S.
AU - Chapman, M.
AU - Chave, H.
AU - Cook, T.
AU - Cuffy, L.
AU - Davies, J.
AU - Dawson, C.
AU - Dixon, J.
AU - Duff, S.
AU - Edwards, C.
AU - Geh, I.
AU - Hamilton, C.
AU - Hancock, L.
AU - Harji, D.
AU - Hill, J.
AU - Holtham, S.
AU - Jenkins, J.
AU - Johnston, R.
AU - Kapur, S.
AU - Maxwell-Armstrong, C.
AU - McArthur, D.
AU - Moran, B.
AU - Norton, C.
AU - Nugent, K.
AU - Pateman, L.
AU - Perston, Y.
AU - Rockall, T.
AU - Sagar, P.
AU - Saunders, M.
AU - Sebag-Montefiore, D.
AU - Senapati, A.
AU - Singh, B.
AU - Skaife, P.
AU - Sykes, H.
AU - Smart, N.
AU - Taylor, C.
AU - Thorpe, G.
AU - Tierney, G.
AU - Voyce, S.
AU - Walsh, C.
AU - Warren, O.
AU - Wheeler, J.
AU - Woodward, A.
AU - Winter, D.
AU - Abbott, S.
AU - Beban, V.
AU - Bennett, M.
AU - Chadwick, T.
AU - Collinson, R.
AU - Corbett, S.
AU - Dennett, E.
AU - Eglinton, T.
AU - Fraser, A.
AU - Glue, J.
AU - Hohaia, D.
AU - Menzi, E.
AU - O'Connor, M.
AU - Stevenson, D.
AU - Wells, C.
AU - Wolyncewicz, S.
AU - Woodfield, J.
AU - Bence, K.
AU - Boutros, M.
AU - Brueseke, M.
AU - DeKorte, J.
AU - Floruta, C.
AU - Francone, T.
AU - Frederick, F.
AU - Grasso, J.
AU - Gurland, B.
AU - Higgins, K.
AU - Hull, T.
AU - Keller, D.
AU - Laffan, A.
AU - Lovett, S.
AU - Marlatt, J.
AU - McAdams, D.
AU - McCarthy, C.
AU - Milch, H.
AU - Natale, S.
AU - Pappou, E.
AU - Paquette, I.
AU - Pulskamp, S.
AU - Rich, M.
AU - Savitt, L.
AU - Shafi, M.
AU - Steele, S.
AU - Stein, S.
AU - Tolbert, M.
AU - Varma, M.
AU - Vogler, S.
AU - Vuong, T.
AU - Wells, K.
AU - Wexner, S.
AU - Wo, J.
AU - Wright, J.
AU - Wunderlich, C.
AU - Campbell, K.
AU - Lim, M.
AU - Moug, S.
AU - Oliphant, R.
AU - Labaka-Aretaga, I.
AU - Ballester, C.
AU - Belen-Bueno, A.
AU - Vaquer-Casas, G.
AU - Jerez, J.
AU - Castillo, J.
AU - Paniagua-Cayetano, G.
AU - Codina-Cazador, A.
AU - Blanco-Colino, R.
AU - de la Portilla, F.
AU - Pascual-Damieta, M.
AU - Enriquez-Navascuez, J. M.
AU - Martin-Fernández, M.
AU - Araujo-Ferreiro, M.
AU - Sanchez-García, C.
AU - Vico-García, E.
AU - Gallego-García, M.
AU - Jimenez, L. M.
AU - Martinez-Sanchez, C.
AU - Carrillo-Moreno, J.
AU - Muñoz, A.
AU - Ramirez, L.
AU - Vigorita, V.
AU - Adams, R.
AU - Cornish, J.
AU - Davies, M.
AU - Evans, M.
AU - Torkington, J.
AU - Turner, J.
N1 - This article is being published concurrently in Diseases of the Colon & Rectum, Colorectal Disease and ANZ Journal of Surgery. The articles are identical exceptfor minor stylistic and spelling differences in keeping with each journal’s style. Citation from any of the three journals can be used when citing this article.
PY - 2020/3
Y1 - 2020/3
N2 - BACKGROUND: Low anterior resection syndrome is pragmatically defined as disordered bowel function after rectal resection leading to a detriment in quality of life. This broad characterization does not allow for precise estimates of prevalence. The low anterior resection syndrome score was designed as a simple tool for clinical evaluation of low anterior resection syndrome. Although the low anterior resection syndrome score has good clinical utility, it may not capture all important aspects that patients may experience. OBJECTIVE: The aim of this collaboration was to develop an international consensus definition of low anterior resection syndrome that encompasses all aspects of the condition and is informed by all stakeholders. DESIGN: This international patient-provider initiative used an online Delphi survey, regional patient consultation meetings, and an international consensus meeting. PARTICIPANTS: Three expert groups participated: patients, surgeons, and other health professionals from 5 regions (Australasia, Denmark, Spain, Great Britain and Ireland, and North America) and in 3 languages (English, Spanish, and Danish). MAIN OUTCOME MEASURE: The primary outcome measured was the priorities for the definition of low anterior resection syndrome. RESULTS: Three hundred twenty-five participants (156 patients) registered. The response rates for successive rounds of the Delphi survey were 86%, 96%, and 99%. Eighteen priorities emerged from the Delphi survey. Patient consultation and consensus meetings refined these priorities to 8 symptoms and 8 consequences that capture essential aspects of the syndrome. LIMITATIONS: Sampling bias may have been present, in particular, in the patient panel because social media was used extensively in recruitment. There was also dominance of the surgical panel at the final consensus meeting despite attempts to mitigate this. CONCLUSIONS: This is the first definition of low anterior resection syndrome developed with direct input from a large international patient panel. The involvement of patients in all phases has ensured that the definition presented encompasses the vital aspects of the patient experience of low anterior resection syndrome. The novel separation of symptoms and consequences may enable greater sensitivity to detect changes in low anterior resection syndrome over time and with intervention.
AB - BACKGROUND: Low anterior resection syndrome is pragmatically defined as disordered bowel function after rectal resection leading to a detriment in quality of life. This broad characterization does not allow for precise estimates of prevalence. The low anterior resection syndrome score was designed as a simple tool for clinical evaluation of low anterior resection syndrome. Although the low anterior resection syndrome score has good clinical utility, it may not capture all important aspects that patients may experience. OBJECTIVE: The aim of this collaboration was to develop an international consensus definition of low anterior resection syndrome that encompasses all aspects of the condition and is informed by all stakeholders. DESIGN: This international patient-provider initiative used an online Delphi survey, regional patient consultation meetings, and an international consensus meeting. PARTICIPANTS: Three expert groups participated: patients, surgeons, and other health professionals from 5 regions (Australasia, Denmark, Spain, Great Britain and Ireland, and North America) and in 3 languages (English, Spanish, and Danish). MAIN OUTCOME MEASURE: The primary outcome measured was the priorities for the definition of low anterior resection syndrome. RESULTS: Three hundred twenty-five participants (156 patients) registered. The response rates for successive rounds of the Delphi survey were 86%, 96%, and 99%. Eighteen priorities emerged from the Delphi survey. Patient consultation and consensus meetings refined these priorities to 8 symptoms and 8 consequences that capture essential aspects of the syndrome. LIMITATIONS: Sampling bias may have been present, in particular, in the patient panel because social media was used extensively in recruitment. There was also dominance of the surgical panel at the final consensus meeting despite attempts to mitigate this. CONCLUSIONS: This is the first definition of low anterior resection syndrome developed with direct input from a large international patient panel. The involvement of patients in all phases has ensured that the definition presented encompasses the vital aspects of the patient experience of low anterior resection syndrome. The novel separation of symptoms and consequences may enable greater sensitivity to detect changes in low anterior resection syndrome over time and with intervention.
KW - Consensus definition
KW - Low anterior resection syndrome
KW - Patient reported
KW - Rectal resection
UR - http://www.scopus.com/inward/record.url?scp=85079083776&partnerID=8YFLogxK
U2 - 10.1097/DCR.0000000000001583
DO - 10.1097/DCR.0000000000001583
M3 - Article
AN - SCOPUS:85079083776
SN - 0012-3706
VL - 63
SP - 274
EP - 284
JO - Diseases of The Colon and Rectum
JF - Diseases of The Colon and Rectum
IS - 3
ER -