Interpreting insulin immunoassays during investigation of apparent spontaneous hypoglycaemia and insulin overdose

Julie Chemmanam, Michelle Isaacs, Graham R. Jones, Jerry R. Greenfield, Morton G. Burt

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    We report two cases of hypoglycaemia; one with apparently spontaneous hypoglycaemia and one with presumed insulin overdose. In both cases insulin concentration was normal when measured with the Roche immunoassay, but elevated when remeasured with the Advia Centaur immunoassay and a diagnosis of hypoglycaemia secondary to insulin analogue administration was made. These cases highlight that physicians need to understand the binding characteristics of the insulin immunoassay they use.

    Original languageEnglish
    Pages (from-to)1448-1451
    Number of pages4
    JournalInternal Medicine Journal
    Volume47
    Issue number12
    DOIs
    Publication statusPublished - Dec 2017

    Keywords

    • factitious hypoglycaemia
    • insulin analogues
    • Roche insulin immunoassay

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