Interpreting insulin immunoassays during investigation of apparent spontaneous hypoglycaemia and insulin overdose

Julie Chemmanam; Michelle Isaacs; Graham R. Jones; Jerry R. Greenfield; Morton G. Burt

doi:10.1111/imj.13644

Interpreting insulin immunoassays during investigation of apparent spontaneous hypoglycaemia and insulin overdose

Julie Chemmanam, Michelle Isaacs, Graham R. Jones, Jerry R. Greenfield, Morton G. Burt

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We report two cases of hypoglycaemia; one with apparently spontaneous hypoglycaemia and one with presumed insulin overdose. In both cases insulin concentration was normal when measured with the Roche immunoassay, but elevated when remeasured with the Advia Centaur immunoassay and a diagnosis of hypoglycaemia secondary to insulin analogue administration was made. These cases highlight that physicians need to understand the binding characteristics of the insulin immunoassay they use.

Original language	English
Pages (from-to)	1448-1451
Number of pages	4
Journal	Internal Medicine Journal
Volume	47
Issue number	12
DOIs	https://doi.org/10.1111/imj.13644
Publication status	Published - Dec 2017

Keywords

factitious hypoglycaemia
insulin analogues
Roche insulin immunoassay

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "We report two cases of hypoglycaemia; one with apparently spontaneous hypoglycaemia and one with presumed insulin overdose. In both cases insulin concentration was normal when measured with the Roche immunoassay, but elevated when remeasured with the Advia Centaur immunoassay and a diagnosis of hypoglycaemia secondary to insulin analogue administration was made. These cases highlight that physicians need to understand the binding characteristics of the insulin immunoassay they use.",

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AB - We report two cases of hypoglycaemia; one with apparently spontaneous hypoglycaemia and one with presumed insulin overdose. In both cases insulin concentration was normal when measured with the Roche immunoassay, but elevated when remeasured with the Advia Centaur immunoassay and a diagnosis of hypoglycaemia secondary to insulin analogue administration was made. These cases highlight that physicians need to understand the binding characteristics of the insulin immunoassay they use.

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Interpreting insulin immunoassays during investigation of apparent spontaneous hypoglycaemia and insulin overdose

Abstract

Keywords

UN SDGs

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