Intersubject and dose‐related variability after intravenous administration of erythromycin.

KL Austin; LE Mather; CR Philpot; PJ McDonald

doi:10.1111/j.1365-2125.1980.tb01755.x

Intersubject and dose‐related variability after intravenous administration of erythromycin.

KL Austin, LE Mather, CR Philpot, PJ McDonald

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Abstract

1 It is well‐known that considerable variability and unpredictability in serum concentrations results from orally administered erythromycin. 2 Disposition kinetics and their variability were studies in 24 healthy subjects after a single dose of erythromycin lactobionate and four doses were studied to evaluate dose‐related variability in five other subjects. 3 Erythromycin kinetics were adequately described by a classical two compartment open model with little intersubject variability. 4 Dose‐related variability occurred. Clearance was independent of dose but T1/2 beta and Vdss increased with dose. 5 Data are presented to show that non‐invasive sampling of urine and saliva are of limited value in studying erythromycin pharmacokinetics. 1980 The British Pharmacological Society

Original language	English
Pages (from-to)	273-279
Number of pages	7
Journal	British Journal of Clinical Pharmacology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2125.1980.tb01755.x
Publication status	Published - Sept 1980

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AB - 1 It is well‐known that considerable variability and unpredictability in serum concentrations results from orally administered erythromycin. 2 Disposition kinetics and their variability were studies in 24 healthy subjects after a single dose of erythromycin lactobionate and four doses were studied to evaluate dose‐related variability in five other subjects. 3 Erythromycin kinetics were adequately described by a classical two compartment open model with little intersubject variability. 4 Dose‐related variability occurred. Clearance was independent of dose but T1/2 beta and Vdss increased with dose. 5 Data are presented to show that non‐invasive sampling of urine and saliva are of limited value in studying erythromycin pharmacokinetics. 1980 The British Pharmacological Society

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Intersubject and dose‐related variability after intravenous administration of erythromycin.

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