Interventions for idiopathic steroid-resistant nephrotic syndrome in children

Elisabeth M. Hodson, Doaa Habashy, Jonathan C. Craig

Research output: Contribution to journalReview articlepeer-review

47 Citations (Scopus)


Cyclosporin may increase the number of children who achieve complete remission in steroid‐resistant nephrotic syndrome. Angiotensin converting enzyme (ACE) inhibitors significantly reduce the degree of proteinuria.

Nephrotic syndrome is a condition where the kidneys leak protein from the blood into the urine. Corticosteroids are used in the first instance to achieve remission. Some children do not respond to this treatment and other agents such as cyclophosphamide, chlorambucil, cyclosporin or ACE inhibitors may be used. This review found that when cyclosporin was compared to placebo or no treatment there was a significant increase in the number of children who achieved complete remission. There was no improvement with other immunosuppressive agents. However the number of studies were small. More research is needed.
Original languageEnglish
Article numberCD003594
JournalCochrane Database of Systematic Reviews
Issue number2
Publication statusPublished - 19 Apr 2006


  • children
  • nephrotic syndrome
  • Cyclosporin


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