Intrahypothalamic injection of somatostatin, not GRF, stimulates prolactin secretion

J. O. Willoughby; R. Kapoor

doi:10.1016/0143-4179(90)90147-Q

Intrahypothalamic injection of somatostatin, not GRF, stimulates prolactin secretion

J. O. Willoughby, R. Kapoor

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The distribution of somatostatin and growth hormone releasing factor (GRF) fibres in the hypothalamus suggests that they may be involved in physiological functions in addition to growth hormone control. GRF or somatostatin were stereotaxically injected into anterior or basal hypothalamic regions of unanesthetized male rats and effects on plasma prolactin measured. Somatostatin caused a small, significant, dose-responsive stimulation of prolactin secretion when injected in both hypothalamic regions, while GRF was without effect. Somatostatin may therefore have a minor intrahypothalamic role in regulating prolactin.

Original language	English
Pages (from-to)	153-156
Number of pages	4
Journal	Neuropeptides
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/0143-4179(90)90147-Q
Publication status	Published - Mar 1990

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title = "Intrahypothalamic injection of somatostatin, not GRF, stimulates prolactin secretion",

abstract = "The distribution of somatostatin and growth hormone releasing factor (GRF) fibres in the hypothalamus suggests that they may be involved in physiological functions in addition to growth hormone control. GRF or somatostatin were stereotaxically injected into anterior or basal hypothalamic regions of unanesthetized male rats and effects on plasma prolactin measured. Somatostatin caused a small, significant, dose-responsive stimulation of prolactin secretion when injected in both hypothalamic regions, while GRF was without effect. Somatostatin may therefore have a minor intrahypothalamic role in regulating prolactin.",

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AU - Willoughby, J. O.

AU - Kapoor, R.

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AB - The distribution of somatostatin and growth hormone releasing factor (GRF) fibres in the hypothalamus suggests that they may be involved in physiological functions in addition to growth hormone control. GRF or somatostatin were stereotaxically injected into anterior or basal hypothalamic regions of unanesthetized male rats and effects on plasma prolactin measured. Somatostatin caused a small, significant, dose-responsive stimulation of prolactin secretion when injected in both hypothalamic regions, while GRF was without effect. Somatostatin may therefore have a minor intrahypothalamic role in regulating prolactin.

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ER -

Intrahypothalamic injection of somatostatin, not GRF, stimulates prolactin secretion

Abstract

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